Hyperinsulinuria in diabetic ketoacidosis

A. Korner, A. Szabo, M. Miltenyi

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Urinary insulin excretion has been measured in diabetic children. In nine well controlled diabetics urinary insulin excretion (mean and 2SD) was significantly greater than that found in healthy controls (8.8; 4.4-17.5 versus 3.8; 2.3-6.4 μU/min/1.73 m2). In ten ketoacidotic diabetic children a 50 fold increase of the urinary insulin excretion has been observed (464.8; 158.2-1363.5 μU/min/1.73 m2). The hyperinsulinuria proved to be reversible: significantly decreased excretion rate (12.9; 9.7-12.3) could be measured 8-10 days after recovery from coma. The hyperinsulinuria during ketoacidosis indicates severe reversible tubular dysfunction. Recurrent ketoacidotic episodes might play a role in the development of diabetic nephropathy.

Original languageEnglish
Pages (from-to)27-30
Number of pages4
JournalInternational Journal of Pediatric Nephrology
Issue number1
Publication statusPublished - Jan 1 1986

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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