Hyperhomocysteinaemia and MTHFR C677T gene polymorphism in renal transplant recipients.

A. J. Szabó, T. Tulassay, B. Melegh, T. Szabó, A. Szabó, A. Vannay, A. Fekete, Z. Süveges, G. Reusz

Research output: Contribution to journalArticle

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Abstract

AIM: To study the effect of folate treatment on hyperhomocysteinaemia and the effect of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism on total homocysteine and folate concentrations after renal transplantation. METHODS: A total of 30 transplanted children and adolescents were investigated for total homocysteine and folate serum concentrations before and after folate treatment, as well as for the presence of the MTHFR C677T polymorphism. RESULTS: The allele frequency of C677T polymorphism in the MTHFR gene in the study population (0.33) was not different to that in controls (0.38). Before folate treatment the homocysteine concentration was raised in all groups; following folate supplementation it was significantly decreased in the CC and CT groups, but not in the TT group. In patients with CC genotype, serum homocysteine correlated with serum creatinine and cholesterol, and time since transplantation before treatment. CONCLUSION: Folate supplementation appears to be an effective strategy to normalise total homocysteine concentration in renal transplanted children and adolescents.

Original languageEnglish
Pages (from-to)47-49
Number of pages3
JournalArchives of Disease in Childhood
Volume85
Issue number1
Publication statusPublished - Jul 2001

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Methylenetetrahydrofolate Reductase (NADPH2)
Hyperhomocysteinemia
Folic Acid
Homocysteine
Kidney
Genes
Serum
Therapeutics
Transplant Recipients
Gene Frequency
Kidney Transplantation
Creatinine
Transplantation
Cholesterol
Genotype
Population

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Hyperhomocysteinaemia and MTHFR C677T gene polymorphism in renal transplant recipients. / Szabó, A. J.; Tulassay, T.; Melegh, B.; Szabó, T.; Szabó, A.; Vannay, A.; Fekete, A.; Süveges, Z.; Reusz, G.

In: Archives of Disease in Childhood, Vol. 85, No. 1, 07.2001, p. 47-49.

Research output: Contribution to journalArticle

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AU - Tulassay, T.

AU - Melegh, B.

AU - Szabó, T.

AU - Szabó, A.

AU - Vannay, A.

AU - Fekete, A.

AU - Süveges, Z.

AU - Reusz, G.

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