Hyperglycemia, type 2 diabetes, and depressive symptoms: The British Whitehall II study

Mika Kivimaki, Adam G. Tabak, G. David Batty, Archana Singh-Manoux, Markus Jokela, Tasnime N. Akbaraly, Daniel R. Witte, Eric J. Brunner, Michael G. Marmot, Debbie A. Lawlor

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

OBJECTIVE - To examine the recent suggestion that impaired fasting glucose may protect against depression, whereas a diagnosis of diabetes might then result in depression. RESEARCH DESIGN AND METHODS - Cross-sectional analysis of 4,228 adults (mean age 60.7 years, 73.0% men) who underwent oral glucose tolerance testing and completed the Center for Epidemiologic Studies Depression scale (CES-D). RESULTS - After adjustment for demographic factors, health behaviors, and clinical measurements (BMI, waist circumference, lipid profile, and blood pressure), there was a U-shaped association between fasting glucose and depression (Pcurve = 0.001), with elevated CES-D at low and very high glucose levels. This finding was replicable with 2-h postload glucose (P = 0.11) and A1C (P = 0.007). CONCLUSIONS - The U-shaped association between blood glucose and CES-D, with the lowest depression risk seen among those in the normoglycemic range of A1C, did not support the hypothesized protective effect of hyperglycemia.

Original languageEnglish
Pages (from-to)1867-1869
Number of pages3
JournalDiabetes care
Volume32
Issue number10
DOIs
Publication statusPublished - Oct 2009

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

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    Kivimaki, M., Tabak, A. G., Batty, G. D., Singh-Manoux, A., Jokela, M., Akbaraly, T. N., Witte, D. R., Brunner, E. J., Marmot, M. G., & Lawlor, D. A. (2009). Hyperglycemia, type 2 diabetes, and depressive symptoms: The British Whitehall II study. Diabetes care, 32(10), 1867-1869. https://doi.org/10.2337/dc09-0716