Hyperaminoacidemia due to the accumulation of gluconeogenic amino acid precursors in hypoglycemic small-for-gestational age infants

J. Mestyán, G. Soltész, K. Schultz, M. Horváth

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The postnatal (3 to 12 hours) plalsma amino acid patterns of normal full-term, nonphypoglycemic, and hypoglycemicsmall-for-gestational age infants were compared. Seventeen amino acids were separated by automatic column chromatography. It was found that hypoglycemia in SGA newborn infants was associated with a marked increase in total serum amino acid concentrations. This hyperaminoacidemia, which was mainly due to the increase in concentrations of aloanine, glycine, proline, and valine, apparently reflected a decreased hepatic gluconeogenic capacity. A significant inverse correlation was observed between concentration of blood glucose and the accumulation of gluconeogenic amino acids. The proportionate accumulation of alanine, glycine, proline, and valine suggests a closely interrelated production and release of these amino acids from the peripheral pools. It is concluded that the changes in concentrations of plasma amino acids occurring in hypoglycemic SGA infants can be helpful in understanding the relative contribution of individual amino acids to gluconeogenesis in the human infants.

Original languageEnglish
Pages (from-to)409-414
Number of pages6
JournalThe Journal of pediatrics
Volume87
Issue number3
DOIs
Publication statusPublished - 1975

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Small for Gestational Age Infant
Hypoglycemic Agents
Amino Acids
Valine
Proline
Glycine
Gluconeogenesis
Hypoglycemia
Alanine
Gestational Age
Blood Glucose
Chromatography
Newborn Infant
Liver
Serum

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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Hyperaminoacidemia due to the accumulation of gluconeogenic amino acid precursors in hypoglycemic small-for-gestational age infants. / Mestyán, J.; Soltész, G.; Schultz, K.; Horváth, M.

In: The Journal of pediatrics, Vol. 87, No. 3, 1975, p. 409-414.

Research output: Contribution to journalArticle

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