Hydrothermal synthesis of Sr-doped hydroxyapatite and its antibacterial activity

Teodóra Nagyné-Kovács, Boglárka Mészáros, Mónika Molnár, Mária Tolner, István Endre Lukács, Imre M. Szilágyi, György Pokol

Research output: Contribution to journalArticle

Abstract

In this study, we prepared hydroxyapatite (HAP) samples using hydrothermal method. We investigated the effect of reaction conditions such as phosphate excess applying 1.49 and 1.67 (as stoichiometric) Ca/P ratio, pH (9/ 10/ 11/ 12) and time (4/ 8/ 12/ 24 h). Sample characterization was carried out by XRD and SEM. The results showed, all samples had HAP structure, however, lower Ca/P ratio, larger reaction time and setting the pH to 10 increased the crystallinity. Then, we synthetized Sr-doped HAP samples, varying the Sr concentration using 2, 4, 6, 8 and 10 % Sr/ (Ca+Sr). The Sr content was revealed by EDX. Sr-incorporation did not change the obtained crystalline HAP phase but the unit cell parameters increased. We calculated lattice constants and found that a, b changed from 9.4310 Å to 9.4700 Å, c from 6.8819 Å to 6.9227 Å and the unit cell volume from 530.0951 Å3 to 537.6556 Å3 due to the larger ionic radius of Sr compared to Ca. The pure and doped samples had uniform, mostly needle-like morphology with 100-300 nm length and 25-100 nm. In vitro cytotoxicity tests revealed evident antibacterial activity in the case of doped samples compared to pure HAP against E. coli.

Original languageEnglish
Pages (from-to)54-60
Number of pages7
JournalPeriodica Polytechnica Chemical Engineering
Volume64
Issue number1
DOIs
Publication statusPublished - Jan 1 2020

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Strontium
Hydrothermal synthesis
Durapatite
Hydroxyapatite
Escherichia coli
Lattice constants
Nanoparticles
Cytotoxicity
Needles
Energy dispersive spectroscopy
Phosphates
Crystalline materials
Scanning electron microscopy
Economics

Keywords

  • Antibacterial activity
  • Hydrothermal
  • Lattice parameters
  • Nanoparticles
  • Sr-doped hydroxyapatite

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Nagyné-Kovács, T., Mészáros, B., Molnár, M., Tolner, M., Lukács, I. E., Szilágyi, I. M., & Pokol, G. (2020). Hydrothermal synthesis of Sr-doped hydroxyapatite and its antibacterial activity. Periodica Polytechnica Chemical Engineering, 64(1), 54-60. https://doi.org/10.3311/PPch.14062

Hydrothermal synthesis of Sr-doped hydroxyapatite and its antibacterial activity. / Nagyné-Kovács, Teodóra; Mészáros, Boglárka; Molnár, Mónika; Tolner, Mária; Lukács, István Endre; Szilágyi, Imre M.; Pokol, György.

In: Periodica Polytechnica Chemical Engineering, Vol. 64, No. 1, 01.01.2020, p. 54-60.

Research output: Contribution to journalArticle

Nagyné-Kovács, T, Mészáros, B, Molnár, M, Tolner, M, Lukács, IE, Szilágyi, IM & Pokol, G 2020, 'Hydrothermal synthesis of Sr-doped hydroxyapatite and its antibacterial activity', Periodica Polytechnica Chemical Engineering, vol. 64, no. 1, pp. 54-60. https://doi.org/10.3311/PPch.14062
Nagyné-Kovács T, Mészáros B, Molnár M, Tolner M, Lukács IE, Szilágyi IM et al. Hydrothermal synthesis of Sr-doped hydroxyapatite and its antibacterial activity. Periodica Polytechnica Chemical Engineering. 2020 Jan 1;64(1):54-60. https://doi.org/10.3311/PPch.14062
Nagyné-Kovács, Teodóra ; Mészáros, Boglárka ; Molnár, Mónika ; Tolner, Mária ; Lukács, István Endre ; Szilágyi, Imre M. ; Pokol, György. / Hydrothermal synthesis of Sr-doped hydroxyapatite and its antibacterial activity. In: Periodica Polytechnica Chemical Engineering. 2020 ; Vol. 64, No. 1. pp. 54-60.
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