Hydrophilic interactions between charged amino acids and the effect of ions on the strength of interaction

Tibor Cserháti, Mária Szögyi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The interaction between oppositely charged amino acids was studied by charge-transfer reversed- phase thin-layer chromatography. The dependence of the lipophilicity of Arg, Lys and Orn on the concentration of G lu, Asp, Gin and Asn in the eluent was considered to be related to the strength of interaction. The interaction o f dibasic am ino acids with Glu and Asp was stronger than with Gin and Asn. Mono - (Li+, Na+, K+, Rb+and Cs+) and divalent (Mg2+ and Ca2+) cations decreased the strength of interaction suggesting the electrostatic character o f the interaction. Their inhibitory effect mainly depended on their concentrationand to a lesser extent on the ion charge and hydrated ion radii. Stepwise regression analysis proved that the strength ofinteraction depends on the polarity parameters of amino acids and is independent of their chemical structure.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalZeitschrift fur naturforschung - section c journal of biosciences
Volume45
Issue number1-2
DOIs
Publication statusPublished - Feb 1 1990

Keywords

  • Charged Amino Acids
  • Hydrophilic Interaction
  • Mono- and Divalent Ions

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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