Hydrogenolysis of N-protected aminooxetanes over palladium: An efficient method for a one-step ring opening and debenzylation reaction

Ervin Kovács, Angelika Thurner, Ferenc Farkas, F. Faigl, L. Hegedûs

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

An efficient method for the palladium mediated hydrogenation of an optically active, N-protected aminooxetane derivative has been developed. Using appropriate solvents, in a one-step reaction, a chiral 1,4-aminoalcohol derivative [(2S,3R)-4-amino-3-benzoyloxy-2-benzylbutan-1-ol] was formed over a Pd/C catalyst, during hydrogenolytic ring opening and debenzylation reactions.

Original languageEnglish
Pages (from-to)32-36
Number of pages5
JournalJournal of Molecular Catalysis A: Chemical
Volume339
Issue number1-2
DOIs
Publication statusPublished - Apr 1 2011

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hydrogenolysis
Hydrogenolysis
Palladium
palladium
Derivatives
rings
Hydrogenation
hydrogenation
catalysts
Catalysts

Keywords

  • Catalytic hydrogenation
  • Chiral 1,4-aminoalcohols
  • Hydrogenolysis
  • Optically active oxetanes
  • Palladium
  • Solvent effects

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Process Chemistry and Technology

Cite this

Hydrogenolysis of N-protected aminooxetanes over palladium : An efficient method for a one-step ring opening and debenzylation reaction. / Kovács, Ervin; Thurner, Angelika; Farkas, Ferenc; Faigl, F.; Hegedûs, L.

In: Journal of Molecular Catalysis A: Chemical, Vol. 339, No. 1-2, 01.04.2011, p. 32-36.

Research output: Contribution to journalArticle

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AU - Hegedûs, L.

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