Hydrogenation of a 4-benzylpyridine derivative over supported precious metal catalysts

Ágnes Proszenyák, B. Ágai, L. Hegedûs, F. Faigl

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The heterogeneous catalytic hydrogenation of 4-(4-fluorobenzyl)pyridine resulted in 4-(4-fluorobenzyl)piperidine, an important and valuable pharmaceutical intermediate. The effects of solvents, temperature, catalytic metals and amount of catalyst on the conversion and the rate of the hydrogenation were investigated. Among the precious metal catalysts applied, the best result was obtained by using a rhodium on carbon catalyst. Palladium or platinum on carbon also showed high activities. This hydrogenation is a key step in an industrially feasible synthesis developed recently.

Original languageEnglish
Pages (from-to)249-253
Number of pages5
JournalApplied Catalysis A: General
Volume269
Issue number1-2
DOIs
Publication statusPublished - Aug 18 2004

Fingerprint

Precious metals
Hydrogenation
Derivatives
Catalysts
Carbon
Rhodium
Palladium
Platinum
Pyridine
Drug products
Metals
Pharmaceutical Preparations
4-benzylpyridine
Temperature

Keywords

  • Benzylpiperidine
  • Benzylpyridine
  • Heterogeneous catalytic hydrogenation
  • Palladium catalyst
  • Rhodium catalyst

ASJC Scopus subject areas

  • Catalysis
  • Process Chemistry and Technology

Cite this

Hydrogenation of a 4-benzylpyridine derivative over supported precious metal catalysts. / Proszenyák, Ágnes; Ágai, B.; Hegedûs, L.; Faigl, F.

In: Applied Catalysis A: General, Vol. 269, No. 1-2, 18.08.2004, p. 249-253.

Research output: Contribution to journalArticle

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