Hybrid mesoporous silica with controlled drug release

L. Almásy, Ana Maria Putz, Qiang Tian, Gennady P. Kopitsa, Tamara V. Khamova, Réka Barabás, Melinda Rigó, A. Bóta, András Wacha, Marius Mirica, Bogdan Ţăranu, Cecilia Savii

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The mesoporous silica particles were prepared by the sol–gel method in one-step synthesis, in acidic conditions, from tetraethoxysilane (TEOS) and methyltriethoxysilane (MTES), varying the mole ratio of the silica precursors. Nitric acid was used as catalyst at room temperature and hexadecyltrimethyl ammonium bromide (CTAB) as structure directing agent. Optical properties, porosity and microstructure of the materials in function of the MTES/TEOS ratio were evaluated using infrared spectroscopy, nitrogen adsorption and small angle X-ray scattering. All materials showed the ordered pore structure and the high specific surfaces, making them suitable as the drug delivery systems. Drug loading and release tests using ketoprofen were performed to assess their performance for drug delivery applications. The amount of the methylated precursor used in the synthesis had little effect on the drug loading capacity, but had a strong influence on the initial rate of the drug release.

Original languageEnglish
Pages (from-to)1027-1039
Number of pages13
JournalJournal of the Serbian Chemical Society
Volume84
Issue number9
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Silicon Dioxide
Pharmaceutical Preparations
Ketoprofen
Nitric Acid
Pore structure
X ray scattering
Drug delivery
Infrared spectroscopy
Nitrogen
Optical properties
Porosity
Adsorption
Microstructure
Catalysts
Temperature
tetraethoxysilane
Drug Delivery Systems
cetrimonium
ammonium bromide

Keywords

  • Hybrid material
  • Ketoprofen
  • SAXS
  • Sol–gel process

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Almásy, L., Putz, A. M., Tian, Q., Kopitsa, G. P., Khamova, T. V., Barabás, R., ... Savii, C. (2019). Hybrid mesoporous silica with controlled drug release. Journal of the Serbian Chemical Society, 84(9), 1027-1039. https://doi.org/10.2298/JSC181109009A

Hybrid mesoporous silica with controlled drug release. / Almásy, L.; Putz, Ana Maria; Tian, Qiang; Kopitsa, Gennady P.; Khamova, Tamara V.; Barabás, Réka; Rigó, Melinda; Bóta, A.; Wacha, András; Mirica, Marius; Ţăranu, Bogdan; Savii, Cecilia.

In: Journal of the Serbian Chemical Society, Vol. 84, No. 9, 01.01.2019, p. 1027-1039.

Research output: Contribution to journalArticle

Almásy, L, Putz, AM, Tian, Q, Kopitsa, GP, Khamova, TV, Barabás, R, Rigó, M, Bóta, A, Wacha, A, Mirica, M, Ţăranu, B & Savii, C 2019, 'Hybrid mesoporous silica with controlled drug release', Journal of the Serbian Chemical Society, vol. 84, no. 9, pp. 1027-1039. https://doi.org/10.2298/JSC181109009A
Almásy L, Putz AM, Tian Q, Kopitsa GP, Khamova TV, Barabás R et al. Hybrid mesoporous silica with controlled drug release. Journal of the Serbian Chemical Society. 2019 Jan 1;84(9):1027-1039. https://doi.org/10.2298/JSC181109009A
Almásy, L. ; Putz, Ana Maria ; Tian, Qiang ; Kopitsa, Gennady P. ; Khamova, Tamara V. ; Barabás, Réka ; Rigó, Melinda ; Bóta, A. ; Wacha, András ; Mirica, Marius ; Ţăranu, Bogdan ; Savii, Cecilia. / Hybrid mesoporous silica with controlled drug release. In: Journal of the Serbian Chemical Society. 2019 ; Vol. 84, No. 9. pp. 1027-1039.
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