Magyarországi ikerkutatások: Négy évtized eredményei

Translated title of the contribution: Hungarian twin studies: Results of four decades

Ádám Domonkos Tárnoki, Dávid László Tárnoki, Tamás Horváth, Júlia Métneki, Levente Littvay

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Twin studies play a role in examining the contribution of genetic variations and environmental factors responsible for the determination of phenotypic variables and of genetic linkage between genotypes. Hungarian twin studies, supported by three twin registries (among them two twin-database), date back to 1970s. Studies mainly focused on various congenital abnormalities, the effect of contraceptive pills and folic acid on the frequency of twin pregnancies, as well as psychosexual and alcohol consumptional behaviors. Monogenic Mendelian inheritance of lactose (mal)absorption was demonstrated for the first time. Hungarian Twin Registry was founded in 2007, which contributed to the current understanding on the background of several disorders, e.g. metabolic syndrome and atherosclerosis. As part of an international twin study, among others, arterial stiffness, central blood pressure, carotid intima/media thickness, venous biomechanics, body composition, lung function and smoking characteristics were also assessed. Absence of genetic background in non-alcoholic fatty liver disease and high inheritance of carotid plaque characteristics were demonstrated for the first time. The review also aims to summarize future plans of the Hungarian Twin Registry.

Translated title of the contributionHungarian twin studies: Results of four decades
Original languageHungarian
Pages (from-to)1579-1586
Number of pages8
JournalOrvosi hetilap
Volume154
Issue number40
DOIs
Publication statusPublished - Oct 1 2013

ASJC Scopus subject areas

  • Medicine(all)

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    Tárnoki, Á. D., Tárnoki, D. L., Horváth, T., Métneki, J., & Littvay, L. (2013). Magyarországi ikerkutatások: Négy évtized eredményei. Orvosi hetilap, 154(40), 1579-1586. https://doi.org/10.1556/OH.2013.29707