A fotoreceptor-kutatas 100 éve

Translated title of the contribution: Hundred years of photoreceptor research

A. Szél, Szabó Arnold, Lukáts Ákos

Research output: Contribution to journalArticle

Abstract

Although color-specific cones differ in their morphological characteristics, histological sections are not suitable for identifying them. The authors tackled this question by using immunocytochemistry on normal histological retinal preparations. They have immunized mice with a cone-rich photoreceptor preparations derived from the retina of chicken. The searching variation of the monoclonal technique was used to identify hybridomas that produced antibodies against photoreceptor and/or cone cells. These hybridomas were further cloned until two stable cell lines have been produced. One of them (OS-2) proved to be specific to short wavelength (S or UV) sensitive cones, whereas another (COS-1) identified cones with green or red visual pigment (M/L pigment). The thorough analysis of the two antibodies has revealed that mammalian cones may express two visual pigments at the same time. The coexpression reflects that the default pathway of cone differentiation is the development of blue-specific cones that may further transdifferentiate to produce the (otherwise) more abundant green-specific cones. The factors that trigger this transition are under intensive investigation. Due to the transdifferentiation process dual cones exhibiting peculiar distribution can be visualized even in adult retinas. They are considered as rudimentary elements.

Original languageHungarian
Pages (from-to)55-61
Number of pages7
JournalOrvoskepzes
Volume86
Issue number1
Publication statusPublished - 2011

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Retinal Cone Photoreceptor Cells
Retinal Pigments
Hybridomas
Retina
Antibodies
Research
Chickens
Color
Immunohistochemistry
Cell Line
Green Or

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Szél, A., Arnold, S., & Ákos, L. (2011). A fotoreceptor-kutatas 100 éve. Orvoskepzes, 86(1), 55-61.

A fotoreceptor-kutatas 100 éve. / Szél, A.; Arnold, Szabó; Ákos, Lukáts.

In: Orvoskepzes, Vol. 86, No. 1, 2011, p. 55-61.

Research output: Contribution to journalArticle

Szél, A, Arnold, S & Ákos, L 2011, 'A fotoreceptor-kutatas 100 éve', Orvoskepzes, vol. 86, no. 1, pp. 55-61.
Szél A, Arnold S, Ákos L. A fotoreceptor-kutatas 100 éve. Orvoskepzes. 2011;86(1):55-61.
Szél, A. ; Arnold, Szabó ; Ákos, Lukáts. / A fotoreceptor-kutatas 100 éve. In: Orvoskepzes. 2011 ; Vol. 86, No. 1. pp. 55-61.
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