Human tumor xenografts as model for drug testing

Jürgen Mattern, Mihaly Bak, Eric W. Hahn, Manfred Volm

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82 Citations (Scopus)

Abstract

This paper reviews the history of xenografts, the endpoints commonly used to evaluate response and chemotherapeutic results obtained with serially maintained human tumor xenografts from different laboratories, and discusses the potential clinical relevance of the heterotransplant model for cancer chemotherapy. Specifically, an attempt is made to correlate the published xenograft data with the clinical data. Drug testing with different types of xenotransplanted tumors has shown that the response of xenografts obtained in immune-deficient animals is comparable to that in clinical practice. In addition, xenografts of a particular tumor type are able to identify agents of known clinical activity against that disease.

Original languageEnglish
Pages (from-to)263-284
Number of pages22
JournalCANCER AND METASTASIS REVIEW
Volume7
Issue number3
DOIs
Publication statusPublished - Nov 1 1988

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Keywords

  • chemotherapy
  • drug testing
  • human tumor xenografts
  • immune-deficient animals

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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