Human trophoblast interferons

George Aboagye-Mathiesen, F. Tóth, Henrik Hager, Milan Zdravkovic, Peter M. Petersen, Jan A. Villadsen, Vladimir Zachar, Peter Ebbesen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The human placental trophoblasts which constitute the first fetal cells and form the major cell layer of the feto-maternal interface are potent producers of interferons (IFNs). The IFN production is dependent on the gestational age of the trophoblast, type of inducer and the stage of differentiation of the trophoblasts. First trimester trophoblast populations produce higher levels (5-6 times) of IFN than the third trimester trophoblasts when stimulated with viruses. Non-viral inducers, such as poly(rl).poly(rC), induce exclusively IFN-β whereas viruses such as Sendai and Newcastle Disease Virus (NDV) induce mixtures of IFN-α subtypes and IFN-β. Differentiation of mononuclear cytotrophoblasts into syncytiotrophoblasts in vitro increase the IFN production. High-performance and immunoaffinity chromatography of the virusinduced trophoblast IFN preparations resulted in the isolation of three antigenically distinct IFNs, namely, αI, αII1 (ω1), and β with molecular masses of 16, 22 and 24 kDa, respectively, on SDS-PAGE. The human trophoblast IFNs have physical and antiviral activities characteristic of the Type 1 IFNs. The possible roles of the trophoblast IFNs in human placental and fetal development are also discussed in this review.

Original languageEnglish
Pages (from-to)91-105
Number of pages15
JournalAntiviral Research
Volume22
Issue number2-3
DOIs
Publication statusPublished - 1993

Fingerprint

Trophoblasts
Interferons
Viruses
Placentation
Newcastle disease virus
Interferon Type I
Third Pregnancy Trimester
Human Development
First Pregnancy Trimester
Fetal Development
Gestational Age
Antiviral Agents
Chromatography
Polyacrylamide Gel Electrophoresis
Mothers

Keywords

  • Interferon
  • Trophoblast interferon

ASJC Scopus subject areas

  • Virology
  • Pharmacology

Cite this

Aboagye-Mathiesen, G., Tóth, F., Hager, H., Zdravkovic, M., Petersen, P. M., Villadsen, J. A., ... Ebbesen, P. (1993). Human trophoblast interferons. Antiviral Research, 22(2-3), 91-105. https://doi.org/10.1016/0166-3542(93)90088-Z

Human trophoblast interferons. / Aboagye-Mathiesen, George; Tóth, F.; Hager, Henrik; Zdravkovic, Milan; Petersen, Peter M.; Villadsen, Jan A.; Zachar, Vladimir; Ebbesen, Peter.

In: Antiviral Research, Vol. 22, No. 2-3, 1993, p. 91-105.

Research output: Contribution to journalArticle

Aboagye-Mathiesen, G, Tóth, F, Hager, H, Zdravkovic, M, Petersen, PM, Villadsen, JA, Zachar, V & Ebbesen, P 1993, 'Human trophoblast interferons', Antiviral Research, vol. 22, no. 2-3, pp. 91-105. https://doi.org/10.1016/0166-3542(93)90088-Z
Aboagye-Mathiesen G, Tóth F, Hager H, Zdravkovic M, Petersen PM, Villadsen JA et al. Human trophoblast interferons. Antiviral Research. 1993;22(2-3):91-105. https://doi.org/10.1016/0166-3542(93)90088-Z
Aboagye-Mathiesen, George ; Tóth, F. ; Hager, Henrik ; Zdravkovic, Milan ; Petersen, Peter M. ; Villadsen, Jan A. ; Zachar, Vladimir ; Ebbesen, Peter. / Human trophoblast interferons. In: Antiviral Research. 1993 ; Vol. 22, No. 2-3. pp. 91-105.
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