A metronidazol (Klion®) human teratogenitasanak vizsgalata

Translated title of the contribution: Human teratologic study of metronidazole

Research output: Contribution to journalArticle


A case-control analysis of congenital malformations following metronidazole treatment in pregnancy has been conducted in the large population-based dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1991. In the study period, of the 30663 pregnant women who have had healthy babies (negative control group), 1041 (3,4%) were treated with metronidazole. Of the 17,300 pregnant women who have had offspring with congenital malformations from the studied pregnancy, 665 (3,8%) were treated with metronidazole. The case-control pair analysis did not show significant difference in the rate of metronidazole treatment in the first trimester of gestation in all but one congenital abnormality groups. The exception was the group with isolated celft lip ± palate. This finding needs further studies. Treatment with metronidazole during pregnancy presents little teratogenic risk to the fetus.

Translated title of the contributionHuman teratologic study of metronidazole
Original languageHungarian
Pages (from-to)297-303
Number of pages7
JournalMagyar Noorvosok Lapja
Issue number4
Publication statusPublished - Jan 1 1997

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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