Human serum amyloid P component attenuates the bacterial lipopolysaccharide-induced increase in blood-brain barrier permeability in mice

Szilvia Veszelka, Zoltán Urbányi, Tamás Pázmány, László Németh, Izabella Obál, Ngo Thi Khue Dung, Csongor S. Ábrahám, Gábor Szabó, Mária A. Deli

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Endotoxin challenge leads to septic shock, multi-organ failure and death in mice. Permeability of the blood-brain barrier (BBB) is increased by endotoxemia. Serum amyloid P component (SAP) is a lipopolysaccharide (LPS)-binding protein that can modulate the host reactions during infections. It is controversial whether SAP can protect from LPS toxicity in vivo or not. We have tested the effect of human SAP on BBB permeability of Salmonella typhimurium LPS-injected mice. The animals showed signs of sickness behaviour including immobility, anorexia, and diarrhoea. Intraperitoneally administered LPS increased the BBB permeability for sodium fluorescein for about 4-fold, and for albumin for more than 2-fold in brain cortex. SAP, given intravenously, had no effect on basal BBB permeability for albumin, although it decreased sodium fluorescein extravasation to brain tissue. In LPS-treated mice, SAP administration alleviated the symptoms of septic shock, and significantly inhibited the enhanced BBB permeability for both tracers. Our data indicate that human SAP may counteract the toxic effects of LPS during septic shock.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalNeuroscience Letters
Volume352
Issue number1
DOIs
Publication statusPublished - Nov 27 2003

Keywords

  • Blood-brain barrier
  • Endotoxemia
  • Lipopolysaccharide
  • Mouse
  • Permeability
  • Serum amyloid P component

ASJC Scopus subject areas

  • Neuroscience(all)

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