Human papillomavirus infection and cervical intraepithelial neoplasia in a cohort of low-risk women

Tibor Nyári, László Kalmár, Csaba Nyári, Louise Parker, László Kovács, László Thurzó

Research output: Contribution to journalArticle

4 Citations (Scopus)


Objective: This study was a prospective examination of the incidence of human papillomavirus (HPV) infection in a low-risk female population and an assessment of the risk of development of LSIL with HPV infection. Study design: In a longitudinal study, women aged 19-60 years - non-smokers, and married or living with a constant partner, who presented for cervical cancer screening at an outpatient clinic - were invited to participate in a prospective study of cervical HPV infection, and were examined every 3 months. Results: Of the 464 women at risk, 20 presented with HPV infections during the follow-up. Low-grade squamous intraepithelial lesions (LSIL) event developed in 18 women. Among these women, 13 were HPV-positive (10 high-risk and 3 low-risk types). The average duration of new LSIL was 20.1 months (95% CI: 13.9-26.3) and 55.3 months (95% CI: 45.7-64.9) in the HPV-positive and negative groups, respectively, the difference was statistically significant (p < 0.001). With the use of Cox proportional hazard regression, we estimated the relative risk as 90.0 for a first instance of LSIL among women testing positive for HPV as compared with women testing negative for HPV. Conclusion: This study has provided evidence that HPV infection is associated with an increased risk of LSIL.

Original languageEnglish
Pages (from-to)246-249
Number of pages4
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Issue number2
Publication statusPublished - Jun 1 2006


  • Carcinoma
  • Cervix
  • HPV-cohort
  • LSIL
  • Prevention

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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