Objective: This study was a prospective examination of the incidence of human papillomavirus (HPV) infection in a low-risk female population and an assessment of the risk of development of LSIL with HPV infection. Study design: In a longitudinal study, women aged 19-60 years - non-smokers, and married or living with a constant partner, who presented for cervical cancer screening at an outpatient clinic - were invited to participate in a prospective study of cervical HPV infection, and were examined every 3 months. Results: Of the 464 women at risk, 20 presented with HPV infections during the follow-up. Low-grade squamous intraepithelial lesions (LSIL) event developed in 18 women. Among these women, 13 were HPV-positive (10 high-risk and 3 low-risk types). The average duration of new LSIL was 20.1 months (95% CI: 13.9-26.3) and 55.3 months (95% CI: 45.7-64.9) in the HPV-positive and negative groups, respectively, the difference was statistically significant (p < 0.001). With the use of Cox proportional hazard regression, we estimated the relative risk as 90.0 for a first instance of LSIL among women testing positive for HPV as compared with women testing negative for HPV. Conclusion: This study has provided evidence that HPV infection is associated with an increased risk of LSIL.
|Number of pages||4|
|Journal||European Journal of Obstetrics and Gynecology and Reproductive Biology|
|Publication status||Published - Jun 1 2006|
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology