Human oocytes containing large cytoplasmic vacuoles can result in pregnancy and viable offspring

Péter Fancsovits, Ákos Murber, Zsuzsa Tóthne Gilán, J. Rigó, J. Urbancsek

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effect of oocyte dysmorphism on further embryo development is controversial. It is generally accepted that serious oocyte abnormalities can have a negative effect on further fertilization and development. A couple reported to the clinic following 2 years of infertility and underwent five IVF/intracytoplasmic sperm injection treatments due to severe male factor infertility. A total of 42 oocytes were collected. The majority of the oocytes showed at least one large, fluid-filled and centrally located cytoplasmic vacuole and unusually thin zona pellucida. Only seven oocytes showed normal fertilization. The first four IVF treatments did not result in pregnancy. In the fifth IVF treatment, three poor-quality vacuolized embryos were transferred. A singleton pregnancy was detected. A baby girl was born at term who required surgery because of a double left kidney and ureter. This case report demonstrates that serious oocyte abnormalities can be a recurrent phenomenon in the same patient. However, the presence of a large vacuole does not completely block the fertilization process and this abnormal cohort of oocytes can still result in normal embryo development and a viable offspring. Rigorous prenatal care and follow-up should be carried out following the transfer of embryos developed from dysmorphic oocytes.

Original languageEnglish
Pages (from-to)513-516
Number of pages4
JournalReproductive BioMedicine Online
Volume23
Issue number4
DOIs
Publication statusPublished - Oct 2011

Fingerprint

Vacuoles
Oocytes
Pregnancy
Fertilization
Embryonic Development
Zona Pellucida
Prenatal Care
Intracytoplasmic Sperm Injections
Embryo Transfer
Male Infertility
Ureter
Infertility
Therapeutics
Embryonic Structures
Kidney

Keywords

  • cytoplasmic vacuole
  • ICSI
  • oocyte morphology
  • oocyte quality

ASJC Scopus subject areas

  • Reproductive Medicine
  • Developmental Biology

Cite this

Human oocytes containing large cytoplasmic vacuoles can result in pregnancy and viable offspring. / Fancsovits, Péter; Murber, Ákos; Gilán, Zsuzsa Tóthne; Rigó, J.; Urbancsek, J.

In: Reproductive BioMedicine Online, Vol. 23, No. 4, 10.2011, p. 513-516.

Research output: Contribution to journalArticle

Fancsovits, Péter ; Murber, Ákos ; Gilán, Zsuzsa Tóthne ; Rigó, J. ; Urbancsek, J. / Human oocytes containing large cytoplasmic vacuoles can result in pregnancy and viable offspring. In: Reproductive BioMedicine Online. 2011 ; Vol. 23, No. 4. pp. 513-516.
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