Human monocytes, macrophages, and dendritic cells: alcohol treatment methods.

Gyongyi Szabo, Pranoti Mandrekar

Research output: Contribution to journalArticle

Abstract

Both acute and chronic alcohol consumption have significant immunomodulatory effects of which alterations in innate immune functions contribute to impaired antimicrobial defense and inflammatory responses. Blood monocytes, macrophages, and dendritic cells play a central role in innate immune recognition as these cells recognize pathogens, respond with inflammatory cytokine production, and induce antigen-specific T-lymphocyte activation. All of these innate immune cell functions are affected in humans by alcohol intake. Here, we summarize the different effects of acute and chronic alcohol on monocyte, macrophage, and dendritic cell functions in humans and describe methods for separation and functional evaluation of these cell types.

Original languageEnglish
Pages (from-to)113-124
Number of pages12
JournalMethods in molecular biology (Clifton, N.J.)
Volume447
Publication statusPublished - 2008

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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