Human monocytes, macrophages, and dendritic cells: Alcohol treatment methods

Gyongyi Szabo, Pranoti Mandrekar

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Citations (Scopus)

Abstract

Both acute and chronic alcohol consumption have significant immunomodulatory effects of which alterations in innate immune functions contribute to impaired antimicrobial defense and inflammatory responses. Blood monocytes, macrophages, and dendritic cells play a central role in innate immune recognition as these cells recognize pathogens, respond with inflammatory cytokine production, and induce antigen-specific T-lymphocyte activation. All of these innate immune cell functions are affected in humans by alcohol intake. Here, we summarize the different effects of acute and chronic alcohol on monocyte, macrophage, and dendritic cell functions in humans and describe methods for separation and functional evaluation of these cell types.

Original languageEnglish
Title of host publicationAlcohol: Methods and Protocols
PublisherHumana Press
Pages113-124
Number of pages12
Volume447
ISBN (Print)9781588299062
DOIs
Publication statusPublished - 2008

Publication series

NameMethods in Molecular Biology
Volume447
ISSN (Print)10643745

Fingerprint

Dendritic Cells
Monocytes
Macrophages
Alcohols
Lymphocyte Activation
Alcohol Drinking
Cytokines
T-Lymphocytes
Antigens

Keywords

  • Dendritic cells
  • Macrophages
  • Monocytes
  • NF-κB.

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Szabo, G., & Mandrekar, P. (2008). Human monocytes, macrophages, and dendritic cells: Alcohol treatment methods. In Alcohol: Methods and Protocols (Vol. 447, pp. 113-124). (Methods in Molecular Biology; Vol. 447). Humana Press. https://doi.org/10.1007/978-1-59745-242-7_9

Human monocytes, macrophages, and dendritic cells : Alcohol treatment methods. / Szabo, Gyongyi; Mandrekar, Pranoti.

Alcohol: Methods and Protocols. Vol. 447 Humana Press, 2008. p. 113-124 (Methods in Molecular Biology; Vol. 447).

Research output: Chapter in Book/Report/Conference proceedingChapter

Szabo, G & Mandrekar, P 2008, Human monocytes, macrophages, and dendritic cells: Alcohol treatment methods. in Alcohol: Methods and Protocols. vol. 447, Methods in Molecular Biology, vol. 447, Humana Press, pp. 113-124. https://doi.org/10.1007/978-1-59745-242-7_9
Szabo G, Mandrekar P. Human monocytes, macrophages, and dendritic cells: Alcohol treatment methods. In Alcohol: Methods and Protocols. Vol. 447. Humana Press. 2008. p. 113-124. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-59745-242-7_9
Szabo, Gyongyi ; Mandrekar, Pranoti. / Human monocytes, macrophages, and dendritic cells : Alcohol treatment methods. Alcohol: Methods and Protocols. Vol. 447 Humana Press, 2008. pp. 113-124 (Methods in Molecular Biology).
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