Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism

S. W. Jansen, A. A. Akintola, F. Roelfsema, E. Van Der Spoel, C. M. Cobbaert, B. E. Ballieux, P. Egri, Z. Kvarta-Papp, B. Gereben, C. Fekete, P. E. Slagboom, J. Van Der Grond, B. A. Demeneix, H. Pijl, R. G J Westendorp, D. Van Heemst

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Abstract

Few studies have included subjects with the propensity to reach old age in good health, with the aim to disentangle mechanisms contributing to staying healthier for longer. The hypothalamic-pituitary-thyroid (HPT) axis maintains circulating levels of thyroid stimulating hormone (TSH) and thyroid hormone (TH) in an inverse relationship. Greater longevity has been associated with higher TSH and lower TH levels, but mechanisms underlying TSH/TH differences and longevity remain unknown. The HPT axis plays a pivotal role in growth, development and energy metabolism. We report that offspring of nonagenarians with at least one nonagenarian sibling have increased TSH secretion but similar bioactivity of TSH and similar TH levels compared to controls. Healthy offspring and spousal controls had similar resting metabolic rate and core body temperature. We propose that pleiotropic effects of the HPT axis may favour longevity without altering energy metabolism.

Original languageEnglish
Article number11525
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - Jun 19 2015

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Thyrotropin
Energy Metabolism
Thyroid Hormones
Thyroid Gland
Basal Metabolism
Body Temperature
Growth and Development
Siblings
Health

ASJC Scopus subject areas

  • General

Cite this

Jansen, S. W., Akintola, A. A., Roelfsema, F., Van Der Spoel, E., Cobbaert, C. M., Ballieux, B. E., ... Van Heemst, D. (2015). Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism. Scientific Reports, 5, [11525]. https://doi.org/10.1038/srep11525

Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism. / Jansen, S. W.; Akintola, A. A.; Roelfsema, F.; Van Der Spoel, E.; Cobbaert, C. M.; Ballieux, B. E.; Egri, P.; Kvarta-Papp, Z.; Gereben, B.; Fekete, C.; Slagboom, P. E.; Van Der Grond, J.; Demeneix, B. A.; Pijl, H.; Westendorp, R. G J; Van Heemst, D.

In: Scientific Reports, Vol. 5, 11525, 19.06.2015.

Research output: Contribution to journalArticle

Jansen, SW, Akintola, AA, Roelfsema, F, Van Der Spoel, E, Cobbaert, CM, Ballieux, BE, Egri, P, Kvarta-Papp, Z, Gereben, B, Fekete, C, Slagboom, PE, Van Der Grond, J, Demeneix, BA, Pijl, H, Westendorp, RGJ & Van Heemst, D 2015, 'Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism', Scientific Reports, vol. 5, 11525. https://doi.org/10.1038/srep11525
Jansen SW, Akintola AA, Roelfsema F, Van Der Spoel E, Cobbaert CM, Ballieux BE et al. Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism. Scientific Reports. 2015 Jun 19;5. 11525. https://doi.org/10.1038/srep11525
Jansen, S. W. ; Akintola, A. A. ; Roelfsema, F. ; Van Der Spoel, E. ; Cobbaert, C. M. ; Ballieux, B. E. ; Egri, P. ; Kvarta-Papp, Z. ; Gereben, B. ; Fekete, C. ; Slagboom, P. E. ; Van Der Grond, J. ; Demeneix, B. A. ; Pijl, H. ; Westendorp, R. G J ; Van Heemst, D. / Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism. In: Scientific Reports. 2015 ; Vol. 5.
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