Human interferons alpha and beta have more potent priming activities than interferon gamma

M. Toth, V. Endresz, S. Toth, I. Beladi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The priming activities of human IFN-α, IFN-β and IFN-γ were compared on the some antiviral basis using human buffy coat leukocytes stimulated with Sendai virus or concanavalin A (Con A) to produce IFN-α or IFN-γ, respectively. Pretreatment of leukocytes with any type of IFN enhanced their IFN-α and IFN-γ production, but IFN-α and IFN-β had more potent priming activities than IFN-γ. IFN-α and IFN-γ did not potentiate the priming activity of each other in either the IFN-α- or the IFN-γ-producing system. Pretreatment of leukocytes with relatively high doses of IFN-α or IFN-β (1000 to 3000 IU/ml) resulted in a 40- to 50-fold increase in the IFN-γ production of Con A-stimulated leukocytes. This observation will be of use in producing IFN-γ with a high titre.

Original languageEnglish
Pages (from-to)893-896
Number of pages4
JournalJournal of General Virology
Volume66
Issue number4
DOIs
Publication statusPublished - Jan 1 1985

ASJC Scopus subject areas

  • Virology

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