Human histologic evaluation of an intrabony defect treated with enamel matrix derivative, xenograft, and GTR

Anton Sculean, P. Windisch, Giovanni Carlo Chiantella

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The purpose of the present case report is to clinically and histologically evaluate the healing of one advanced intrabony defect following treatment with an enamel matrix protein derivative (EMD) combined with a bovine-derived xenograft (BDX) and guided tissue regeneration (GTR). One patient with generalized chronic periodontitis and one advanced intrabony defect was treated with EMD + BDX + GTR. Notches were placed in the root at the level of the calculus and alveolar crest to aid histologic identification of new periodontal tissues. Postoperative healing was uneventful. At the 7-month histologic examination, healing in the intrabony component of the defect was characterized by formation of new connective tissue attachment (new cellular cementum with inserting collagen fibers) and new bone in the intrabony component. The BDX particles were surrounded by bone-like tissue. No direct contact between the graft particles and root surface (cementum or dentin) was observed. Healing in the suprabony defect component occurred through epithelial downgrowth that stopped at the level of the coronal notch. The BDX particles were entirely encapsulated in dense connective tissue, without any signs of bone formation. The present case report shows formation of new attachment apparatus consisting of new bone, cementum, and periodontal ligament in the intrabony component of one human defect treated with EMD + BDX + GTR.

Original languageEnglish
Pages (from-to)326-333
Number of pages8
JournalInternational Journal of Periodontics and Restorative Dentistry
Volume24
Issue number4
Publication statusPublished - Aug 2004

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Guided Tissue Regeneration
Dental Enamel
Heterografts
Dental Cementum
Bone and Bones
Connective Tissue
Chronic Periodontitis
Periodontal Ligament
Calculi
Dentin
Osteogenesis
Collagen
Transplants
enamel matrix proteins

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Human histologic evaluation of an intrabony defect treated with enamel matrix derivative, xenograft, and GTR. / Sculean, Anton; Windisch, P.; Chiantella, Giovanni Carlo.

In: International Journal of Periodontics and Restorative Dentistry, Vol. 24, No. 4, 08.2004, p. 326-333.

Research output: Contribution to journalArticle

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