Human herpesvirus 8 in hematologic diseases

G. Mikala, Jiuru Xie, G. Berencsi, C. Kiss, I. Márton, Gyula Domján, István Vályi-Nagy

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Human herpesvirus type 8 (HHV-8), also known as Kaposi's sarcoma- associated herpesvirus (KSHV) is a new member of the γ-herpesvirus family. It is an unusual herpesvirus in that it carries a large number of genes that encode oncoproteins or cell signaling proteins. In addition to being the causative agent of both HIV-associated and non-HIV-associated Kaposi's sarcoma this DNA tumor virus has been implicated in the pathogenesis of several diseases. These include multiple myeloma (MM), Waldenstrom's macroglobulinemia (WM), multicentric Castleman's disease (MCD), body cavity- based lymphoma (BCBL), and various other conditions such as sarcoidosis and pemphigus. While the causative role of the viral infection is fairly certain in the development of BCBL and multicentric Castleman's disease, HHV-8 may act through a different mechanism to induce plasma cell malignancies. It has been suggested - though the finding is still controversial that infection of bone marrow stromal dendritic cells by HHV-8 might be a key factor in the etiology and pathogenesis of monoclonal gammopathies. The aim of this review is to provide a short introduction into the tumorigenic potential of HHV-8 as well as to detail the available data and possible mechanisms on the involvement of this virus in different hematologic diseases.

Original languageEnglish
Pages (from-to)73-79
Number of pages7
JournalPathology and Oncology Research
Volume5
Issue number1
DOIs
Publication statusPublished - Mar 1999

Fingerprint

Human Herpesvirus 8
Hematologic Diseases
Herpesviridae
Lymphoma
DNA Tumor Viruses
Waldenstrom Macroglobulinemia
Paraproteinemias
Pemphigus
Kaposi's Sarcoma
Oncogene Proteins
Virus Diseases
Sarcoidosis
Plasma Cells
Multiple Myeloma
Mesenchymal Stromal Cells
Dendritic Cells
HIV
Viruses
Infection
Genes

Keywords

  • HHV-8
  • Tumorigenesis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Human herpesvirus 8 in hematologic diseases. / Mikala, G.; Xie, Jiuru; Berencsi, G.; Kiss, C.; Márton, I.; Domján, Gyula; Vályi-Nagy, István.

In: Pathology and Oncology Research, Vol. 5, No. 1, 03.1999, p. 73-79.

Research output: Contribution to journalArticle

Mikala, G. ; Xie, Jiuru ; Berencsi, G. ; Kiss, C. ; Márton, I. ; Domján, Gyula ; Vályi-Nagy, István. / Human herpesvirus 8 in hematologic diseases. In: Pathology and Oncology Research. 1999 ; Vol. 5, No. 1. pp. 73-79.
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