Human germinal mutagenic effects in relation to intentional and accidental exposure to toxic agents

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This paper presents examples of epidemiological evaluation of exposure- and cluster-type mutations in human populations. The self-poisoning model did not show that offspring born from mothers after a semilethal self-poisoning had higher rates of prenatal selection (fetal death) or abnormalities due to germinal mutations; however, an intrauterine growth retardation was found. The surveillance function of the Hungarian Congenital Abnormality Registry has detected many cluster-type situations, one example of which is an extreme increase of Down's syndrome in a small Hungarian village in 1989 to 1990. Environmental investigations have pointed to the excessive use of trichlorfon at local fish farms as the cause.

Original languageEnglish
Pages (from-to)615-617
Number of pages3
JournalEnvironmental Health Perspectives
Volume104
Issue numberSUPPL. 3
Publication statusPublished - May 1996

Fingerprint

Trichlorfon
Poisons
abnormality
poisoning
Poisoning
Fish
Farms
mutation
Fisheries
Mutation
Fetal Death
Fetal Growth Retardation
Down Syndrome
Registries
village
farm
fish
Population
exposure
effect

Keywords

  • Down's syndrome
  • Intrauterine growth retardation
  • Mutation epidemiology
  • Self-poisoning model
  • Spatial cluster
  • Trichlorfon

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Human germinal mutagenic effects in relation to intentional and accidental exposure to toxic agents. / Czeizel, E.

In: Environmental Health Perspectives, Vol. 104, No. SUPPL. 3, 05.1996, p. 615-617.

Research output: Contribution to journalArticle

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