Human germinal mutagenic effects in relation to intentional and accidental exposure to toxic agents

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This paper presents examples of epidemiological evaluation of exposure- and cluster-type mutations in human populations. The self-poisoning model did not show that offspring born from mothers after a semilethal self-poisoning had higher rates of prenatal selection (fetal death) or abnormalities due to germinal mutations; however, an intrauterine growth retardation was found. The surveillance function of the Hungarian Congenital Abnormality Registry has detected many cluster-type situations, one example of which is an extreme increase of Down's syndrome in a small Hungarian village in 1989 to 1990. Environmental investigations have pointed to the excessive use of trichlorfon at local fish farms as the cause.

Original languageEnglish
Pages (from-to)615-617
Number of pages3
JournalEnvironmental Health Perspectives
Volume104
Issue numberSUPPL. 3
DOIs
Publication statusPublished - May 1996

Keywords

  • Down's syndrome
  • Intrauterine growth retardation
  • Mutation epidemiology
  • Self-poisoning model
  • Spatial cluster
  • Trichlorfon

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Fingerprint Dive into the research topics of 'Human germinal mutagenic effects in relation to intentional and accidental exposure to toxic agents'. Together they form a unique fingerprint.

  • Cite this