Human female hair follicles are a direct, nonclassical target for thyroid-stimulating hormone

E. Bódó, Arno Kromminga, T. Bíró, István Borbíró, Erzsébet Gáspár, Michal A. Zmijewski, Nina Van Beek, Lutz Langbein, Andrzej T. Slominski, Ralf Paus

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Pituitary thyroid-stimulating hormone (TSH) regulates thyroid hormone synthesis via receptors (TSH-R) expressed on thyroid epithelial cells. As the hair follicle (HF) is uniquely hormone-sensitive and, hypothyroidism with its associated, increased TSH serum levels clinically can lead to hair loss, we asked whether human HFs are a direct target for TSH. Here, we report that normal human scalp skin and microdissected human HFs express TSH-R mRNA. TSH-R-like immunoreactivity is limited to the mesenchymal skin compartments in situ. TSH may alter HF mesenchymal functions, as it upregulates α-smooth muscle actin expression in HF fibroblasts. TSH-R stimulation by its natural ligand in organ culture changes the expression of several genes of human scalp HFs (for example keratin K5), upregulates the transcription of classical TSH target genes and enhances cAMP production. Although the functional role of TSH in human HF biology awaits further dissection, these findings document that intracutaneous TSH-Rs are fully functional in situ and that HFs of female individuals are direct targets for nonclassical, extrathyroidal TSH bioregulation. This suggests that organ-cultured scalp HFs provide an instructive and physiologically relevant human model for exploring nonclassical functions of TSH, in and beyond the skin.

Original languageEnglish
Pages (from-to)1126-1139
Number of pages14
JournalJournal of Investigative Dermatology
Volume129
Issue number5
DOIs
Publication statusPublished - May 2009

Fingerprint

Hair Follicle
Thyrotropin
Scalp
Skin
Up-Regulation
Genes
Thyrotropin Receptors
Dissection
Pituitary Hormones
Organ Culture Techniques
Alopecia
Transcription
Fibroblasts
Keratins
Hypothyroidism
Thyroid Hormones
Cell culture
Smooth Muscle
Muscle
Actins

ASJC Scopus subject areas

  • Dermatology
  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Human female hair follicles are a direct, nonclassical target for thyroid-stimulating hormone. / Bódó, E.; Kromminga, Arno; Bíró, T.; Borbíró, István; Gáspár, Erzsébet; Zmijewski, Michal A.; Van Beek, Nina; Langbein, Lutz; Slominski, Andrzej T.; Paus, Ralf.

In: Journal of Investigative Dermatology, Vol. 129, No. 5, 05.2009, p. 1126-1139.

Research output: Contribution to journalArticle

Bódó, E, Kromminga, A, Bíró, T, Borbíró, I, Gáspár, E, Zmijewski, MA, Van Beek, N, Langbein, L, Slominski, AT & Paus, R 2009, 'Human female hair follicles are a direct, nonclassical target for thyroid-stimulating hormone', Journal of Investigative Dermatology, vol. 129, no. 5, pp. 1126-1139. https://doi.org/10.1038/jid.2008.361
Bódó, E. ; Kromminga, Arno ; Bíró, T. ; Borbíró, István ; Gáspár, Erzsébet ; Zmijewski, Michal A. ; Van Beek, Nina ; Langbein, Lutz ; Slominski, Andrzej T. ; Paus, Ralf. / Human female hair follicles are a direct, nonclassical target for thyroid-stimulating hormone. In: Journal of Investigative Dermatology. 2009 ; Vol. 129, No. 5. pp. 1126-1139.
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