Human gyogyszermetabolizalo enzimek III. Epoxid hidrolazok, eszterazok es amidazok

Translated title of the contribution: Human drug metabolizing enzymes III. Epoxide hydrolases, esterases and amidases

Hazai Eszter, Róna Kálmán, Vereczkey László

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In this review we focus on human hydrolytic enzymes that participate in the metabolism of xenobiotics. Although hydrolysis in most of the cases result in detoxication, in some cases hydrolysis may lead to activated molecules that may attack macromolecules (proteins, RNAs, DNAs), resulting in toxicity. We have summarised the data available on these enzymes concerning their catalytic profile and specificity, inhibition, induction properties, their possible role in the generation of toxic compounds, their importance in clinical practice and drug development.

Original languageHungarian
Pages (from-to)208-212
Number of pages5
JournalActa pharmaceutica Hungarica
Volume69
Issue number4
Publication statusPublished - Sep 1 1999

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ASJC Scopus subject areas

  • Pharmaceutical Science

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