In this review we focus on human oxidative enzymes that are responsible for the metabolism of xenobiotics. More and more publications prove that the reactions catalysed by these enzymes very often lead to activated molecules that may attack macromolecules (proteins, RNAs, DNAs), resulting in toxicity (liver, neuro-, embryotoxicity, allergy, carcinogenecity). We have summarised the data available on these enzymes, concerning their catalytic profile and specificity, inhibition, induction properties, their possible role in the generation of toxic compounds, their importance in clinical practice and drug development.
|Translated title of the contribution||Human drug metabolizing enzymes I. Oxidative enzymes|
|Number of pages||8|
|Journal||Acta pharmaceutica Hungarica|
|Publication status||Published - Sep 1 1998|
ASJC Scopus subject areas
- Pharmaceutical Science