Human chorionic gonadotropin (HCG)-like hormones (FSH, LH, TSH) in Tetrahymena. A confocal microscopic analysis

G. Csaba, Péter Kovács

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The unicellular ciliate, Tetrahymena contains molecules which immunologically and functionally resemble to human hormones. Up to now, of the pituitary glycoprotein hormones only the presence of adrenocorticotropic hormone (ACTH) was demonstrated. In the present experiment we observed the presence of molecules immunologically similar to human chorionic gonadotropin (HCG). This hormone-like material is localized diffusely in the cell, and in higher amount in the cortical region, in the cilia and in the oral field. After one hour treatment (hormonal imprinting) with luteinizing hormone (LH), follicle stimulating hormone, mixture of these two hormones, HCG, or thyrotropic hormone (TSH), more fluorescence intensity (given by the hormone) can be observed. Twenty four hours or four days after these treatments the amount of hormone-like materials seems to be higher, than in the untreated cells or immediately after treatment. The diffuse localization disappears in the body of the cell after LH or FSH treatment and the hormone concentrates peripheral, in the cortex and especially in (or on) the cilia. The largest amount of hormone-like material seems to be present after LH+FSH or TSH treatment. These results mean that in Tetrahymena enhanced production of the appropriate hormone could be induced by hormone treatment (imprinting), which is maintained in the progeny generations. The experiments support that hormonal imprinting of receptor and hormone production can run parallel.

Original languageEnglish
Pages (from-to)191-198
Number of pages8
JournalActa Protozoologica
Volume39
Issue number3
Publication statusPublished - 2000

Fingerprint

Tetrahymena
human chorionic gonadotropin
Chorionic Gonadotropin
luteinizing hormone
Luteinizing Hormone
hormones
Hormones
Cilia
cilia
thyrotropin
Pituitary Hormones
follicle-stimulating hormone
corticotropin
Follicle Stimulating Hormone
cells
Ciliophora
Adrenocorticotropic Hormone
glycoproteins
mouth
Glycoproteins

Keywords

  • Gonadotropins
  • Hormonal imprinting
  • Pituitary hormones
  • Tetrahymena
  • TSH

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)
  • Microbiology

Cite this

Human chorionic gonadotropin (HCG)-like hormones (FSH, LH, TSH) in Tetrahymena. A confocal microscopic analysis. / Csaba, G.; Kovács, Péter.

In: Acta Protozoologica, Vol. 39, No. 3, 2000, p. 191-198.

Research output: Contribution to journalArticle

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