Human atherosclerotic abdominal aortic aneurysms produce interleukin (IL)-6 and interferon-gamma but not IL-2 and IL-4: The possible role for IL-6 and interferon-gamma in vascular inflammation

Z. Szekanecz, Manisha R. Shah, William H. Pearce, Alisa E. Koch

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Immunological mechanisms play an important role in the pathogenesis of atherosclerosis and atherosclerotic abdominal aortic aneurysms (AAA). Inflammatory leukocytes invade the vessel wall and produce cytokines which perpetuate the immune events underlying these diseases. Interleukin (IL)-1β, IL-8, tumor necrosis factor-α, and monocyte chemoattractant protein-1, among others, may play a role in the generation by AAA. The aim of this study was to investigate the possible pathogenetic role of other proinflammatory cytokines, namely IL-2, IL-4, IL-6, and interferon (IFN)-gamma. Enzyme-linked immunosorbent assay of human explant culture supernatants revealed a significant increase in IFN-gamma production by AAA compared to occlusive (atherosclerotic) or normal (NL) aortic explants. IL-6 production was also increased in AAA compared to NL aortic explant supernatants. Neither AAA nor NL aortic tissues produced IL-2 or IL-4 in the same culture system. These results suggest that IL-6, a cytokine involved in T and B lymphocyte activation during inflammation, and IFN-gamma, which stimulates T and B lymphocytes, macrophages, endothelial cells and fibroblasts, may play a role in the pathogenesis of various vascular inflammatory diseases such as AAA.

Original languageEnglish
Pages (from-to)159-162
Number of pages4
JournalAgents and Actions
Volume42
Issue number3-4
DOIs
Publication statusPublished - Oct 1994

Fingerprint

Abdominal Aortic Aneurysm
Interleukin-4
Interferon-gamma
Interleukin-2
Blood Vessels
Interleukin-6
Lymphocytes
Cytokines
Inflammation
Immunosorbents
Chemokine CCL2
Macrophages
Endothelial cells
Fibroblasts
Interleukin-8
Interleukin-1
Assays
B-Lymphocytes
Tumor Necrosis Factor-alpha
Chemical activation

Keywords

  • Aneurysm
  • Atherosclerosis
  • Cytokine

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

Cite this

Human atherosclerotic abdominal aortic aneurysms produce interleukin (IL)-6 and interferon-gamma but not IL-2 and IL-4 : The possible role for IL-6 and interferon-gamma in vascular inflammation. / Szekanecz, Z.; Shah, Manisha R.; Pearce, William H.; Koch, Alisa E.

In: Agents and Actions, Vol. 42, No. 3-4, 10.1994, p. 159-162.

Research output: Contribution to journalArticle

@article{6e2e1b54deae4306b5cc29b66cb4650d,
title = "Human atherosclerotic abdominal aortic aneurysms produce interleukin (IL)-6 and interferon-gamma but not IL-2 and IL-4: The possible role for IL-6 and interferon-gamma in vascular inflammation",
abstract = "Immunological mechanisms play an important role in the pathogenesis of atherosclerosis and atherosclerotic abdominal aortic aneurysms (AAA). Inflammatory leukocytes invade the vessel wall and produce cytokines which perpetuate the immune events underlying these diseases. Interleukin (IL)-1β, IL-8, tumor necrosis factor-α, and monocyte chemoattractant protein-1, among others, may play a role in the generation by AAA. The aim of this study was to investigate the possible pathogenetic role of other proinflammatory cytokines, namely IL-2, IL-4, IL-6, and interferon (IFN)-gamma. Enzyme-linked immunosorbent assay of human explant culture supernatants revealed a significant increase in IFN-gamma production by AAA compared to occlusive (atherosclerotic) or normal (NL) aortic explants. IL-6 production was also increased in AAA compared to NL aortic explant supernatants. Neither AAA nor NL aortic tissues produced IL-2 or IL-4 in the same culture system. These results suggest that IL-6, a cytokine involved in T and B lymphocyte activation during inflammation, and IFN-gamma, which stimulates T and B lymphocytes, macrophages, endothelial cells and fibroblasts, may play a role in the pathogenesis of various vascular inflammatory diseases such as AAA.",
keywords = "Aneurysm, Atherosclerosis, Cytokine",
author = "Z. Szekanecz and Shah, {Manisha R.} and Pearce, {William H.} and Koch, {Alisa E.}",
year = "1994",
month = "10",
doi = "10.1007/BF01983484",
language = "English",
volume = "42",
pages = "159--162",
journal = "Inflammation Research",
issn = "1023-3830",
publisher = "Birkhauser Verlag Basel",
number = "3-4",

}

TY - JOUR

T1 - Human atherosclerotic abdominal aortic aneurysms produce interleukin (IL)-6 and interferon-gamma but not IL-2 and IL-4

T2 - The possible role for IL-6 and interferon-gamma in vascular inflammation

AU - Szekanecz, Z.

AU - Shah, Manisha R.

AU - Pearce, William H.

AU - Koch, Alisa E.

PY - 1994/10

Y1 - 1994/10

N2 - Immunological mechanisms play an important role in the pathogenesis of atherosclerosis and atherosclerotic abdominal aortic aneurysms (AAA). Inflammatory leukocytes invade the vessel wall and produce cytokines which perpetuate the immune events underlying these diseases. Interleukin (IL)-1β, IL-8, tumor necrosis factor-α, and monocyte chemoattractant protein-1, among others, may play a role in the generation by AAA. The aim of this study was to investigate the possible pathogenetic role of other proinflammatory cytokines, namely IL-2, IL-4, IL-6, and interferon (IFN)-gamma. Enzyme-linked immunosorbent assay of human explant culture supernatants revealed a significant increase in IFN-gamma production by AAA compared to occlusive (atherosclerotic) or normal (NL) aortic explants. IL-6 production was also increased in AAA compared to NL aortic explant supernatants. Neither AAA nor NL aortic tissues produced IL-2 or IL-4 in the same culture system. These results suggest that IL-6, a cytokine involved in T and B lymphocyte activation during inflammation, and IFN-gamma, which stimulates T and B lymphocytes, macrophages, endothelial cells and fibroblasts, may play a role in the pathogenesis of various vascular inflammatory diseases such as AAA.

AB - Immunological mechanisms play an important role in the pathogenesis of atherosclerosis and atherosclerotic abdominal aortic aneurysms (AAA). Inflammatory leukocytes invade the vessel wall and produce cytokines which perpetuate the immune events underlying these diseases. Interleukin (IL)-1β, IL-8, tumor necrosis factor-α, and monocyte chemoattractant protein-1, among others, may play a role in the generation by AAA. The aim of this study was to investigate the possible pathogenetic role of other proinflammatory cytokines, namely IL-2, IL-4, IL-6, and interferon (IFN)-gamma. Enzyme-linked immunosorbent assay of human explant culture supernatants revealed a significant increase in IFN-gamma production by AAA compared to occlusive (atherosclerotic) or normal (NL) aortic explants. IL-6 production was also increased in AAA compared to NL aortic explant supernatants. Neither AAA nor NL aortic tissues produced IL-2 or IL-4 in the same culture system. These results suggest that IL-6, a cytokine involved in T and B lymphocyte activation during inflammation, and IFN-gamma, which stimulates T and B lymphocytes, macrophages, endothelial cells and fibroblasts, may play a role in the pathogenesis of various vascular inflammatory diseases such as AAA.

KW - Aneurysm

KW - Atherosclerosis

KW - Cytokine

UR - http://www.scopus.com/inward/record.url?scp=0028171227&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028171227&partnerID=8YFLogxK

U2 - 10.1007/BF01983484

DO - 10.1007/BF01983484

M3 - Article

C2 - 7879703

AN - SCOPUS:0028171227

VL - 42

SP - 159

EP - 162

JO - Inflammation Research

JF - Inflammation Research

SN - 1023-3830

IS - 3-4

ER -