Human and experimental hepatocarcinogenesis

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Human liver cancer is increasing worldwide, including in Hungary. The detection of liver tumors in premalignant or early malignant states is essential for successful treatment. MC-29 virus-induced chicken hepatoma and rodent, fish and monkey models for chemical hepatocarcinogenesis were studied and compared to humans. Changes in phenotypic enzyme alterations and in the expression of certain oncogens and growth factors characterize the experimentally induced hepatomas, and might also be characteristic of human premalignant and malignant focal liver lesions. Fish hepatocarcinogenesis is useful for studying compounds in environmental pollution. Increased expression of transforming growth factor a can be observed both in experimental and human liver tumors. Increased tumor incidence was detected in transgene mice containing both transforming growth factor α and c-myc genes. Animal models of hepatocarcinogenesis help to understand the development of liver tumors. Methods applied in studies using those models are useful in the study of premalignant and malignant human liver lesions.

Original languageEnglish
Pages (from-to)90-97
Number of pages8
JournalScandinavian Journal of Gastroenterology, Supplement
Issue number228
Publication statusPublished - Dec 15 1998


  • Experimental models
  • Hepatocarcinogenesis
  • Hepatocellular carcinoma
  • Liver

ASJC Scopus subject areas

  • Gastroenterology

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