Human amyloid-β1-42 applied in vivo inhibits the fast axonal transport of proteins in the sciatic nerve of rat

P. Kása, Henrietta Papp, Imre Kovacs, Monika Forgon, B. Penke, Haruyasu Yamaguchi

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Human amyloid-β1-42 has been suggested to be a pathogenetic factor in Alzheimer's disease. The precise mechanism by which this peptide causes the degeneration of neurons in the affected brain is not yet fully understood. By using immunohistochemistry we explored the inhibitory effects of human amyloid-β1-42 applied in vivo on the fast axonal transport of acetylcholinesterase, the amyloid precursor protein, the vesicular acetylcholine transporter and synaptophysin in the sciatic nerve of rat. Our findings provide evidence for the in vivo neurotoxic effect of human amyloid- β peptide.

Original languageEnglish
Pages (from-to)117-119
Number of pages3
JournalNeuroscience Letters
Volume278
Issue number1-2
DOIs
Publication statusPublished - Jan 7 2000

Fingerprint

Axonal Transport
Sciatic Nerve
Amyloid
Carrier Proteins
Vesicular Acetylcholine Transport Proteins
Nerve Degeneration
Synaptophysin
Peptides
Amyloid beta-Protein Precursor
Acetylcholinesterase
Alzheimer Disease
Immunohistochemistry
Brain

Keywords

  • Alzheimer's disease
  • Amyloid
  • Axonal transport
  • Immunohistochemistry
  • Neurotoxicity
  • Sciatic nerve

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Human amyloid-β1-42 applied in vivo inhibits the fast axonal transport of proteins in the sciatic nerve of rat. / Kása, P.; Papp, Henrietta; Kovacs, Imre; Forgon, Monika; Penke, B.; Yamaguchi, Haruyasu.

In: Neuroscience Letters, Vol. 278, No. 1-2, 07.01.2000, p. 117-119.

Research output: Contribution to journalArticle

Kása, P. ; Papp, Henrietta ; Kovacs, Imre ; Forgon, Monika ; Penke, B. ; Yamaguchi, Haruyasu. / Human amyloid-β1-42 applied in vivo inhibits the fast axonal transport of proteins in the sciatic nerve of rat. In: Neuroscience Letters. 2000 ; Vol. 278, No. 1-2. pp. 117-119.
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