HtrA1 is a novel mast cell serine protease of mice and men

Anna Gilicze, Barbara Kohalmi, Peter Pocza, Marton Keszei, Judit Jaeger, Eva Gorbe, Zoltan Papp, Sara Toth, Andras Falus, Zoltan Wiener

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Mast cells are rich sources of proteases, such as tryptases and chymases that control many physiological and pathological processes, for example vascular permeability, smooth muscle cell proliferation or extracellular matrix remodeling. Murine mucosal mast cells mature under the influence of TGF-β and play a role in asthmatic and anti-helminthic immune responses. In an attempt to identify novel genes that are highly upregulated during mucosal mast cell differentiation, we detected HtrA1 protease as a novel protein in mast cells by microarray experiments. HtrA1 level was much higher in murine mucosal than in connective tissue-type mast cells. Furthermore, HtrA1 is not localized in the secretory granules and is constitutively secreted by human mast cells. Although HtrA1 has been attributed a TGF-β-inhibitory activity, it did not show any influence on TGF-β-induced mucosal mast cell differentiation. As many extracellular target proteins have been suggested for HtrA1, this protease may participate in the mast cell-induced extracellular remodeling.

Original languageEnglish
Pages (from-to)2961-2968
Number of pages8
JournalMolecular Immunology
Volume44
Issue number11
DOIs
Publication statusPublished - Apr 1 2007

Keywords

  • HtrA1
  • Human MC(T) cell
  • Microarray
  • Mucosal mast cell
  • Transforming growth factor-beta

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

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  • Cite this

    Gilicze, A., Kohalmi, B., Pocza, P., Keszei, M., Jaeger, J., Gorbe, E., Papp, Z., Toth, S., Falus, A., & Wiener, Z. (2007). HtrA1 is a novel mast cell serine protease of mice and men. Molecular Immunology, 44(11), 2961-2968. https://doi.org/10.1016/j.molimm.2007.01.004