HTLV-related markers in a hungarian patient with adult T-cell leukemia

Jolàn Kiss, Béla Telek, F. Tóth, László Rejto, Péter Surányi, Kálmán Rák

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Monoclonal integration of DNA sequences related to, but not identical to HTLV-I provirus was detected in the peripheral blood lymphocytes of a Hungarian male suffering from ATL. The patient and his parents showed serological cross-reactivity with both HTLV-I and HTLV-II groupspecific antigens. Restriction enzyme analysis with EcoR1, Pstl, BamH1, HindIII and Sacl revealed structural similarity of the provirus integrated in the DNA of ATL cells to HTLV-I but not to HTLV-II. Data suggest that this provirus and HTLV-I are similar to each other along gag and pol regions, but they are different in the env region.

Original languageEnglish
Pages (from-to)1125-1131
Number of pages7
JournalLeukemia Research
Volume16
Issue number11
DOIs
Publication statusPublished - 1992

Fingerprint

Adult T Cell Leukemia Lymphoma
Human T-lymphotropic virus 1
Proviruses
HTLV-II Antigens
Human T-lymphotropic virus 2
Restriction Mapping
Psychological Stress
Parents
Lymphocytes
DNA

Keywords

  • ATL
  • cross-reacting antibodies
  • familial cluster of carriers
  • HTLV-related proviral DNA

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

HTLV-related markers in a hungarian patient with adult T-cell leukemia. / Kiss, Jolàn; Telek, Béla; Tóth, F.; Rejto, László; Surányi, Péter; Rák, Kálmán.

In: Leukemia Research, Vol. 16, No. 11, 1992, p. 1125-1131.

Research output: Contribution to journalArticle

Kiss, J, Telek, B, Tóth, F, Rejto, L, Surányi, P & Rák, K 1992, 'HTLV-related markers in a hungarian patient with adult T-cell leukemia', Leukemia Research, vol. 16, no. 11, pp. 1125-1131. https://doi.org/10.1016/0145-2126(92)90051-8
Kiss, Jolàn ; Telek, Béla ; Tóth, F. ; Rejto, László ; Surányi, Péter ; Rák, Kálmán. / HTLV-related markers in a hungarian patient with adult T-cell leukemia. In: Leukemia Research. 1992 ; Vol. 16, No. 11. pp. 1125-1131.
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