HTLV-I-related retroviral markers in Hungarian patients with mycosis fungoides.

J. Kiss, T. Tisza, F. Tóth, A. Horváth, A. Stumpf

Research output: Contribution to journalArticle

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Abstract

Cell and serum samples from 7 Hungarian patients with mycosis fungoides were examined for the presence of HTLV-I-related DNA sequences and antibodies recognizing HTLV-I antigens. DNA sequences distantly related to the proviral DNA of HTLV-I were shown by Southern blot hybridization in 3 patients. Serum samples from these patients contained antibodies reactive with the internal core polypeptides of HTLV-I and HTLV-II, but not with the env gene encoded type-specific HTLV antigens. Restriction enzyme analysis with EcoRI, PstI, BamHI and SacI revealed structural similarity of the provirus(es) integrated in the DNA of mycosis fungoides cells to HTLV-I but not to HTLV-II. Data suggest that these proviruses and HTLV-I are similar to each other along gag and pol regions.

Original languageEnglish
Pages (from-to)123-130
Number of pages8
JournalActa Microbiologica Hungarica
Volume40
Issue number2
Publication statusPublished - 1993

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Mycosis Fungoides
Human T-lymphotropic virus 1
Human T-lymphotropic virus 2
Proviruses
Deltaretrovirus Antigens
HTLV-I Antigens
env Genes
Restriction Mapping
Antibodies
DNA
Southern Blotting
Serum
Peptides

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

HTLV-I-related retroviral markers in Hungarian patients with mycosis fungoides. / Kiss, J.; Tisza, T.; Tóth, F.; Horváth, A.; Stumpf, A.

In: Acta Microbiologica Hungarica, Vol. 40, No. 2, 1993, p. 123-130.

Research output: Contribution to journalArticle

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