Hsp70 interactions with membrane lipids regulate cellular functions in health and disease

Zsolt Balogi, Gabrielle Multhoff, Thomas Kirkegaard Jensen, Emyr Lloyd-Evans, Tetsumori Yamashima, Marja Jäättelä, John L. Harwood, L. Vígh

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Beyond guarding the cellular proteome the major stress inducible heat shock protein Hsp70 has been shown to interact with lipids. Non-cytosolic Hsp70 stabilizes membranes during stress challenges and, in pathophysiological states, facilitates endocytosis, counteracts apoptotic mechanisms, sustains survival pathways or represents a signal that can be recognized by the immune system. Disease-coupled lipid-associated functions of Hsp70 may be targeted via distinct subcellular localizations of Hsp70 itself or its specific interacting lipids. With a special focus on interacting lipids, here we discuss localization-dependent roles of the membrane-bound Hsp70 in the context of its therapeutic potential, particularly in cancer and neurodegenerative diseases.

Original languageEnglish
Pages (from-to)18-30
Number of pages13
JournalProgress in Lipid Research
Volume74
DOIs
Publication statusPublished - Apr 1 2019

Fingerprint

Membrane Lipids
Health
Lipids
Neurodegenerative diseases
Membranes
Immune system
Proteome
Heat-Shock Proteins
Endocytosis
Neurodegenerative Diseases
Immune System
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Hsp70 interactions with membrane lipids regulate cellular functions in health and disease. / Balogi, Zsolt; Multhoff, Gabrielle; Jensen, Thomas Kirkegaard; Lloyd-Evans, Emyr; Yamashima, Tetsumori; Jäättelä, Marja; Harwood, John L.; Vígh, L.

In: Progress in Lipid Research, Vol. 74, 01.04.2019, p. 18-30.

Research output: Contribution to journalReview article

Balogi, Z, Multhoff, G, Jensen, TK, Lloyd-Evans, E, Yamashima, T, Jäättelä, M, Harwood, JL & Vígh, L 2019, 'Hsp70 interactions with membrane lipids regulate cellular functions in health and disease', Progress in Lipid Research, vol. 74, pp. 18-30. https://doi.org/10.1016/j.plipres.2019.01.004
Balogi Z, Multhoff G, Jensen TK, Lloyd-Evans E, Yamashima T, Jäättelä M et al. Hsp70 interactions with membrane lipids regulate cellular functions in health and disease. Progress in Lipid Research. 2019 Apr 1;74:18-30. https://doi.org/10.1016/j.plipres.2019.01.004
Balogi, Zsolt ; Multhoff, Gabrielle ; Jensen, Thomas Kirkegaard ; Lloyd-Evans, Emyr ; Yamashima, Tetsumori ; Jäättelä, Marja ; Harwood, John L. ; Vígh, L. / Hsp70 interactions with membrane lipids regulate cellular functions in health and disease. In: Progress in Lipid Research. 2019 ; Vol. 74. pp. 18-30.
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