HPLC investigation of a set of local anesthetic aminoether derivatives

G. Szász, H. Oelschlager, K. Takács-Novák, T. Takacs-Novak

Research output: Contribution to journalArticle

Abstract

A series of amino-alkylaryl-ether and thioether derivatives with local anesthetic activity was investigated in an IP-RP HPLC system. Good correlation was found between the retention (log k') and octanol-water partition coefficient (log P). The values of the correlation coefficients gradually increased with the increasing concentration of the ion-pairing agent, sodium dodecyl sulfate (NaDS). This experience is interpreted by the similar interaction in the partition and chromatographic systems. The Δlog k' and π values generated from the log k' and log P values of the compounds having basic nucleus, showed also a good correlation.

Original languageEnglish
Pages (from-to)2341-2353
Number of pages13
JournalJournal of Liquid Chromatography
Volume15
Issue number13
Publication statusPublished - 1992

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Octanols
Sulfides
Local Anesthetics
Sodium Dodecyl Sulfate
Ether
High Pressure Liquid Chromatography
Ions
Derivatives
Water

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

HPLC investigation of a set of local anesthetic aminoether derivatives. / Szász, G.; Oelschlager, H.; Takács-Novák, K.; Takacs-Novak, T.

In: Journal of Liquid Chromatography, Vol. 15, No. 13, 1992, p. 2341-2353.

Research output: Contribution to journalArticle

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