HPLC investigation of 11-amino undecanoic acid's ion pairing ability on fluoroquinolone gyrase inhibitors

Zs Budvari Barany, A. Lore, G. Szász, K. Takács-Novák, I. Hermecz

Research output: Contribution to journalArticle

Abstract

The bonding of 11-aminoundecanoic (11-AA), 8-amino octanoic and 6-aminohexanoic acids as representatives of Zwitterionic ion-pairing agents, was determined on C18 column in the pH range 3-8. The break through curve of 11-AA has shown minimum in the vicinity of the isoelectric point. In the same pH range the chromatographic behaviour of fluoroquinolone gyrase inhibitor derivatives was studied in 0.002 M 11-AA containing methanol-phosphate buffer (1:1) eluent. The retention of the fluoroquinolones has shown a maximum close to the pH of the isoelectric points. As explanation the adsorption of the neutral form is suggested by the authors. The reverse chromatographic behaviour of 11-AA and the fluoroquinolone lomefloxacin harmonizes well with the results of pH dependent species distribution.

Original languageEnglish
Pages (from-to)2031-2044
Number of pages14
JournalJournal of the Institute of Energy
Volume67
Issue number470
Publication statusPublished - Mar 1994

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inhibitors
amino acids
Amino acids
Phosphates
Methanol
Derivatives
Adsorption
Acids
Ions
ions
phosphates
methyl alcohol
buffers
acids
adsorption
curves

ASJC Scopus subject areas

  • Energy Engineering and Power Technology
  • Fuel Technology

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HPLC investigation of 11-amino undecanoic acid's ion pairing ability on fluoroquinolone gyrase inhibitors. / Barany, Zs Budvari; Lore, A.; Szász, G.; Takács-Novák, K.; Hermecz, I.

In: Journal of the Institute of Energy, Vol. 67, No. 470, 03.1994, p. 2031-2044.

Research output: Contribution to journalArticle

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