Hplc investigation of 11-amino undecanoic acid’s ion pairing ability on fluoroquinolone gyrase inhibitors

Zs Budvãšri Bárány, A. Lüre, Gy Szász, K. Tak Úcs-Novãšk, I. Hermecz

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The bonding of 11-aminoundecanoic (11-AA), 8-amino octanoic and 6-aminohexanoic acids as representatives of Zwitterionic ion-pairing agents, was determined on C18column in the pH range 3–8. The break through curve of 11 - AA has shown minimum in the vicinity of the isoelectric point. In the same pH range the chromatographic behaviour of fluoroquinolone gyrase inhibitor derivatives was studied in 0.002 M 11-AA containing methanol-phosphate buffer (1:1) eluent. The retention of the fluoroquinolones has shown a maximum close to the pH of the isoelectric points. As explanation the adsorption of the neutral form is suggested by the authors. The reverse chromatographic behaviour of 11-AA and the fluoroquinolone lomefloxacin harmonizes well with the results of pH dependent species distribution.

Original languageEnglish
Pages (from-to)2031-2044
Number of pages14
JournalJournal of Liquid Chromatography
Issue number9
Publication statusPublished - May 1 1994


ASJC Scopus subject areas

  • Molecular Medicine

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