HPLC enantioseparation of 1-(α-aminobenzyl)-2-naphthol and 2-(α-aminobenzyl)-1-naphthol analogs on a β-cyclodextrin-based chiral stationary phase

R. Berkecz, I. Ilisz, A. Ivanov-Sztojkov, I. Szatmári, F. Fülöp, D. W. Armstrong, A. Péter

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20 Citations (Scopus)

Abstract

The enantiomers of 1-(α-aminobenzyl)-2-naphthol and 2-(α-aminobenzyl)-1-naphthol analogs were separated isothermally on a 3,5-dimethylphenylcarbamoylated β-cyclodextrin-based chiral stationary phase (Cyclobond DMP), with an n-hexane/alcohol modifier as mobile phase. Optimization of the separation was achieved by variation of combinations of the polar mobile phase additives ethanol and methanol. The nature and position of the α-aminobenzyl substituent of the 1- and 2-naphthol analogs influenced the retention and the selectivity.

Original languageEnglish
Pages (from-to)337-341
Number of pages5
JournalChromatographia
Volume65
Issue number5-6
DOIs
Publication statusPublished - Mar 1 2007

Keywords

  • 1-(α-Aminobenzyl)- 2-naphthol analogs
  • 2-(α-Aminobenzyl)-1-naphthol analogs
  • Column liquid chromatography
  • Cyclobond column
  • Enantiomer separation

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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