HPLC analysis of metabolically produced formaldehyde

J. Lengyel, H. Kalász, T. Szarvas, Cs Peltz, A. Szarkáné-Bolehovszky

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Radiolabelled (-)-deprenyl is orally administered to rats, and urinary elimination of radiolabelled formaldehyde is detected. The separation is performed using high-performance liquid chromatography on octadecyl-silica stationary phase. Both the radioactivity and the UV absorbance of the dinitrophenylhydrazine formaldehyde peak are determined. Formaldehyde generation takes place by N-demethylation. Low levels of formaldehyde may have a beneficial role in counterbalancing the oxidative stress of the everyday person's life.

Original languageEnglish
Pages (from-to)177-181
Number of pages5
JournalJournal of Chromatographic Science
Volume41
Issue number4
Publication statusPublished - Apr 2003

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Formaldehyde
High Pressure Liquid Chromatography
Selegiline
Oxidative stress
Radioactivity
High performance liquid chromatography
Silicon Dioxide
Rats
Oxidative Stress

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry

Cite this

Lengyel, J., Kalász, H., Szarvas, T., Peltz, C., & Szarkáné-Bolehovszky, A. (2003). HPLC analysis of metabolically produced formaldehyde. Journal of Chromatographic Science, 41(4), 177-181.

HPLC analysis of metabolically produced formaldehyde. / Lengyel, J.; Kalász, H.; Szarvas, T.; Peltz, Cs; Szarkáné-Bolehovszky, A.

In: Journal of Chromatographic Science, Vol. 41, No. 4, 04.2003, p. 177-181.

Research output: Contribution to journalArticle

Lengyel, J, Kalász, H, Szarvas, T, Peltz, C & Szarkáné-Bolehovszky, A 2003, 'HPLC analysis of metabolically produced formaldehyde', Journal of Chromatographic Science, vol. 41, no. 4, pp. 177-181.
Lengyel J, Kalász H, Szarvas T, Peltz C, Szarkáné-Bolehovszky A. HPLC analysis of metabolically produced formaldehyde. Journal of Chromatographic Science. 2003 Apr;41(4):177-181.
Lengyel, J. ; Kalász, H. ; Szarvas, T. ; Peltz, Cs ; Szarkáné-Bolehovszky, A. / HPLC analysis of metabolically produced formaldehyde. In: Journal of Chromatographic Science. 2003 ; Vol. 41, No. 4. pp. 177-181.
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