HPLC analysis in drug level monitoring of K027

S. Nurulain, H. Kalász, P. Szegi, K. Kuca, A. Adem, M. Hasan, F. Hashemi, K. Tekes

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5 Citations (Scopus)

Abstract

HPLC monitoring of pharmacokinetics was done in two body compartments of rats following intramuscular treatments with three different doses of K027, a bispyridinium mono-aldoxime type of antidotes to organoposphate intoxicated subjects. Reversed-phase HPLC separation with electrochemical detections was done to monitor the onset, the maximum level, and offset in K027 concentration. Serum level of K027 showed a fast onset, independently from the doses of K027. Drug level in brain was showing an essentially delayed kinetics.

Original languageEnglish
Pages (from-to)703-710
Number of pages8
JournalActa Chromatographica
Volume25
Issue number4
DOIs
Publication statusPublished - Dec 1 2013

Keywords

  • HPLC
  • K027
  • blood-brain barrier
  • pharmacokinetics
  • quantitation
  • reversed-phase separation

ASJC Scopus subject areas

  • Chemistry(all)

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    Nurulain, S., Kalász, H., Szegi, P., Kuca, K., Adem, A., Hasan, M., Hashemi, F., & Tekes, K. (2013). HPLC analysis in drug level monitoring of K027. Acta Chromatographica, 25(4), 703-710. https://doi.org/10.1556/AChrom.25.2013.4.8