HPLC analysis and detection of L-deprenyl

V. Csomor, R. Laufer, Z. Pöstényi, H. Kalász, E. Adeghate, S. M. Nurulain, K. Tekes, A. Adem

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

L-Deprenyl and its major metabolites were subjected to reversed-phase highperformance liquid chromatography (HPLC). The separation was monitored using both ultraviolet (UV) and electrochemical detectors. Ultraviolet absorbance detected L-deprenyl, L-nordeprenyl, L-methamphetamine, and L-amphetamine. Amperometric detection was specific and sensitive to the parent compound (L-deprenyl, a tertiary amine) only. Peaks of the major L-deprenyl metabolites did not give any comparable signal using amperometric monitoring.

Original languageEnglish
Pages (from-to)649-656
Number of pages8
JournalActa Chromatographica
Volume26
Issue number4
DOIs
Publication statusPublished - Dec 1 2014

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Selegiline
Liquid chromatography
Metabolites
Methamphetamine
Amphetamine
Amines
Detectors
Monitoring

Keywords

  • Amperometric detection
  • HPLC
  • L-deprenyl
  • Metabolites
  • UV detection

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Csomor, V., Laufer, R., Pöstényi, Z., Kalász, H., Adeghate, E., Nurulain, S. M., ... Adem, A. (2014). HPLC analysis and detection of L-deprenyl. Acta Chromatographica, 26(4), 649-656. https://doi.org/10.1556/AChrom.26.2014.4.7

HPLC analysis and detection of L-deprenyl. / Csomor, V.; Laufer, R.; Pöstényi, Z.; Kalász, H.; Adeghate, E.; Nurulain, S. M.; Tekes, K.; Adem, A.

In: Acta Chromatographica, Vol. 26, No. 4, 01.12.2014, p. 649-656.

Research output: Contribution to journalArticle

Csomor, V, Laufer, R, Pöstényi, Z, Kalász, H, Adeghate, E, Nurulain, SM, Tekes, K & Adem, A 2014, 'HPLC analysis and detection of L-deprenyl', Acta Chromatographica, vol. 26, no. 4, pp. 649-656. https://doi.org/10.1556/AChrom.26.2014.4.7
Csomor V, Laufer R, Pöstényi Z, Kalász H, Adeghate E, Nurulain SM et al. HPLC analysis and detection of L-deprenyl. Acta Chromatographica. 2014 Dec 1;26(4):649-656. https://doi.org/10.1556/AChrom.26.2014.4.7
Csomor, V. ; Laufer, R. ; Pöstényi, Z. ; Kalász, H. ; Adeghate, E. ; Nurulain, S. M. ; Tekes, K. ; Adem, A. / HPLC analysis and detection of L-deprenyl. In: Acta Chromatographica. 2014 ; Vol. 26, No. 4. pp. 649-656.
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