HPLC analysis and detection of L-deprenyl

V. Csomor, R. Laufer, Z. Pöstényi, H. Kalász, E. Adeghate, S. M. Nurulain, K. Tekes, A. Adem

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2 Citations (Scopus)

Abstract

L-Deprenyl and its major metabolites were subjected to reversed-phase highperformance liquid chromatography (HPLC). The separation was monitored using both ultraviolet (UV) and electrochemical detectors. Ultraviolet absorbance detected L-deprenyl, L-nordeprenyl, L-methamphetamine, and L-amphetamine. Amperometric detection was specific and sensitive to the parent compound (L-deprenyl, a tertiary amine) only. Peaks of the major L-deprenyl metabolites did not give any comparable signal using amperometric monitoring.

Original languageEnglish
Pages (from-to)649-656
Number of pages8
JournalActa Chromatographica
Volume26
Issue number4
DOIs
Publication statusPublished - Dec 1 2014

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Keywords

  • Amperometric detection
  • HPLC
  • L-deprenyl
  • Metabolites
  • UV detection

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Csomor, V., Laufer, R., Pöstényi, Z., Kalász, H., Adeghate, E., Nurulain, S. M., Tekes, K., & Adem, A. (2014). HPLC analysis and detection of L-deprenyl. Acta Chromatographica, 26(4), 649-656. https://doi.org/10.1556/AChrom.26.2014.4.7