HPLC analysis and blood-brain penetration of 20-hydroxyecdysone diacetonide

H. Kalász, Attila Hunyadi, K. Tekes, Rafael Dolesal, Gellért Karvaly

Research output: Contribution to journalArticle

Abstract

Blood-brain penetration of 20-hydroxyecdysone 2,3;20,22-diacetonide (20DA) has been scouted using chromatographic methods. In vivo experiments were performed by treating male Wistar rats intraperitoneally (i.p.) with a dose of 50 mg kg-1 20DA. Control experiment was done by using 20-hydroxyecdysone (20E). Definite brain penetration of 20DA was found by using high-performance liquid chromatography (HPLC), while 20E does not show this type of distribution.

Original languageEnglish
Pages (from-to)375-383
Number of pages9
JournalActa Chromatographica
Volume29
Issue number3
DOIs
Publication statusPublished - Sep 1 2017

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Ecdysterone
High performance liquid chromatography
Brain
Blood
Rats
Experiments

Keywords

  • 20-hydroxyecdysone 2,3;20,22-diacetonide
  • Blood-brain barrier penetration
  • Distribution
  • Ecdysteroid
  • HPLC

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

HPLC analysis and blood-brain penetration of 20-hydroxyecdysone diacetonide. / Kalász, H.; Hunyadi, Attila; Tekes, K.; Dolesal, Rafael; Karvaly, Gellért.

In: Acta Chromatographica, Vol. 29, No. 3, 01.09.2017, p. 375-383.

Research output: Contribution to journalArticle

Kalász, H. ; Hunyadi, Attila ; Tekes, K. ; Dolesal, Rafael ; Karvaly, Gellért. / HPLC analysis and blood-brain penetration of 20-hydroxyecdysone diacetonide. In: Acta Chromatographica. 2017 ; Vol. 29, No. 3. pp. 375-383.
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