Hox Proteins Mediate Developmental and Environmental Control of Autophagy

Agnes Banreti, Bruno Hudry, M. Sass, AndrewJ Saurin, Yacine Graba

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Hox genes encode evolutionarily conserved transcription factors, providing positional information used for differential morphogenesis along the anteroposterior axis. Here, we show that Drosophila Hox proteins are potent repressors of the autophagic process. In inhibiting autophagy, Hox proteins display no apparent paralog specificity and do not provide positional information. Instead, they impose temporality on developmental autophagy and act as effectors of environmental signals in starvation-induced autophagy. Further characterization establishes that temporality is controlled by Pontin, a facultative component of the Brahma chromatin remodeling complex, and that Hox proteins impact on autophagy by repressing the expression of core components of the autophagy machinery. Finally, the potential of central and posterior mouse Hox proteins to inhibit autophagy in Drosophila and in vertebrate COS-7 cells indicates that regulation of autophagy is an evolutionary conserved feature of Hox proteins.

Original languageEnglish
Pages (from-to)56-69
Number of pages14
JournalDevelopmental Cell
Volume28
Issue number1
DOIs
Publication statusPublished - Jan 13 2014

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Autophagy
Proteins
Repressor Proteins
Chromatin
Machinery
Transcription Factors
Genes
Drosophila Proteins
Chromatin Assembly and Disassembly
Homeobox Genes
COS Cells
Starvation
Morphogenesis
Drosophila
Vertebrates

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Hox Proteins Mediate Developmental and Environmental Control of Autophagy. / Banreti, Agnes; Hudry, Bruno; Sass, M.; Saurin, AndrewJ; Graba, Yacine.

In: Developmental Cell, Vol. 28, No. 1, 13.01.2014, p. 56-69.

Research output: Contribution to journalArticle

Banreti, Agnes ; Hudry, Bruno ; Sass, M. ; Saurin, AndrewJ ; Graba, Yacine. / Hox Proteins Mediate Developmental and Environmental Control of Autophagy. In: Developmental Cell. 2014 ; Vol. 28, No. 1. pp. 56-69.
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