How many Ca2+ATPase isoforms are expressed in a cell type? A growing family of membrane proteins illustrated by studies in platelets

R. Bobe, R. Bredoux, E. Corvazier, C. Lacabaratz-Porret, V. Martin, T. Kovács, J. Enouf

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Ca2+ signaling plays a key role in normal and abnormal platelet functions. Understanding platelet Ca2+ signaling requires the knowledge of proteins involved in this process. Among these proteins are Ca 2+ATPases or Ca2+ pumps that deplete the cytosol of Ca2+ ions. Here, we will particularly focus on two Ca2+ pump families: the plasma membrane Ca2+ATPases (PMCAs) that extrude cytosolic Ca2+ towards the extracellular medium and the sarco/endoplasmic reticulum Ca2+ATPases (SERCAs) that pump Ca 2+ into the endoplasmic reticulum (ER). In the present review, we will summarize data on platelet Ca2+ATPases including their identification and biogenesis. First of all, we will present the Ca 2+ATPase genes and their isoforms expressed in platelets. We will especially focus on a member of the SERCA family, SERCA3, recently found to give rise to a number of species-specific isoforms. Next, we will describe the differences in Ca2+ATPase patterns observed in human and rat platelets. Last, we will analyze how the expression of Ca2+ATPase isoforms changes during megakaryocytic maturation and show that megakaryocytopoiesis is associated with a profound reorganization of the expression and/or activity of Ca2+ATPases. Taken together, these data provide new aspects of investigations to better understand normal and abnormal platelet Ca2+ signaling.

Original languageEnglish
Pages (from-to)133-150
Number of pages18
JournalPlatelets
Volume16
Issue number3-4
DOIs
Publication statusPublished - May 2005

Fingerprint

Calcium-Transporting ATPases
Protein Isoforms
Membrane Proteins
Blood Platelets
Sarcoplasmic Reticulum Calcium-Transporting ATPases
Thrombopoiesis
Endoplasmic Reticulum
Cytosol
Adenosine Triphosphatases
Proteins
Cell Membrane
Ions
Genes

Keywords

  • Ca
  • CaATPases
  • Isoforms
  • Megakaryocytes
  • Platelets

ASJC Scopus subject areas

  • Hematology
  • Cell Biology

Cite this

How many Ca2+ATPase isoforms are expressed in a cell type? A growing family of membrane proteins illustrated by studies in platelets. / Bobe, R.; Bredoux, R.; Corvazier, E.; Lacabaratz-Porret, C.; Martin, V.; Kovács, T.; Enouf, J.

In: Platelets, Vol. 16, No. 3-4, 05.2005, p. 133-150.

Research output: Contribution to journalArticle

Bobe, R. ; Bredoux, R. ; Corvazier, E. ; Lacabaratz-Porret, C. ; Martin, V. ; Kovács, T. ; Enouf, J. / How many Ca2+ATPase isoforms are expressed in a cell type? A growing family of membrane proteins illustrated by studies in platelets. In: Platelets. 2005 ; Vol. 16, No. 3-4. pp. 133-150.
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