In hydatidiform mole the pathologic structure and function of placenta lead to abnormal pregnancy without viable fetus. Some of these diseases may develop into malignant trophoblast tumors with local uterine invasion or far metastases. Malignant trophoblast diseases can be treated exceedingly because of their extremely good response for chemotherapy. A long time follow up of patients is very important after uterine evacuation. Regular control of serum β-hCG titers accurately indicates the state of the disease, the recovery, the remission, and increasing titers can evidence the relapse, respectively. Current follow up protocols suggest weekly serum β-hCG controls until undetectable titers are reached, then monthly checks for several months to verify the remission of the disease. According to the analysis of 550 patients' data, our workgroup did not find any case, where the continuously decreasing hCG titers indicated relapse of molar pregnancy after reaching undetectable levels, during monthly controls. Developing into malignant trophoblastic tumors after hCG titers fell to zero seems to be extremely rare. Although prolonged monthly checks are advisable for the patients, it may be appropriate to reconsider the duration of currently suggested follow up. Perhaps - if further analyses of data report similar experiences - a shorter follow up protocol may be sufficient after hydatidiform mole.
|Number of pages||4|
|Publication status||Published - Dec 1 2003|
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