How long should patients be followed after molar pregnancy? Analysis of serum hCG follow-up data

Jozsef Batorfi, Gyorgy Vegh, Janos Szepesi, Ivan Szigetvari, Jozsef Doszpod, Vilmos Fulop

Research output: Contribution to journalArticle

27 Citations (Scopus)


Objective: We analyzed human chorionic gonadotropin (hCG) follow-up data of patients with molar pregnancy. Women often do not complete recommended post-disease screening. Our purpose was to determine if continuing follow up of uncomplicated molar cases beyond attaining undetectable hCG levels is necessary for detecting relapse of gestational trophoblastic disease. Study design: One hundred fifty patients treated at Hungarian National Health Center were analyzed. Those who developed persistent disease before hCG had become undetectable were excluded from further analysis (n=24; 16%). Results: Among 126 uncomplicated cases, 72 patients (57%) completed follow up, and 54 (43%) discontinued their protocol before it had been completed. Of 120 patients who achieved at least one undetectable hCG level, none had any evidence of relapse. Conclusion: In uncomplicated hydatidiform mole, our analysis indicates that once undetectable serum hCG levels are attained, relapse is unlikely. Although further monthly checks are advisable, the likelihood of recurrence appears very low.

Original languageEnglish
Pages (from-to)95-97
Number of pages3
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Issue number1
Publication statusPublished - Jan 15 2004



  • Complete and partial hydatidiform mole
  • Follow up
  • Gestational trophoblastic disease
  • Human chorionic gonadotropin
  • hCG

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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