How and why nanoparticle's curvature regulates the apparent pKa of the coating ligands

Dawei Wang, Rikkert J. Nap, István Lagzi, Bartlomiej Kowalczyk, Shuangbing Han, Bartosz A. Grzybowski, Igal Szleifer

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

Dissociation of ionizable ligands immobilized on nanopaticles (NPs) depends on and can be regulated by the curvature of these particles as well as the size and the concentration of counterions. The apparent acid dissociation constant (pKa) of the NP-immobilized ligands lies between that of free ligands and ligands self-assembled on a flat surface. This phenomenon is explicitly rationalized by a theoretical model that accounts fully for the molecular details (size, shape, conformation, and charge distribution) of both the NPs and the counterions.

Original languageEnglish
Pages (from-to)2192-2197
Number of pages6
JournalJournal of the American Chemical Society
Volume133
Issue number7
DOIs
Publication statusPublished - Feb 23 2011

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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