Hot topics and trends in cardiovascular research

Diane Gal, Bart Thijs, W. Glänzel, Karin R. Sipido

Research output: Contribution to journalArticle

Abstract

AIMS: Comprehensive data on research undertaken in cardiovascular medicine can inform the scientific community and can support policy building. We used the publication output from 2004 to 2013 and the 2014 references to these documents, to identify research topics and trends in the field of cardiovascular disease. METHODS AND RESULTS: Text fragments were extracted from the titles and abstracts of 478 000 publications using natural language processing. Through machine-learning algorithms, these text fragments combined to identify specific topics across all publications. A second method, which included cross-references, assigned each publication document to a specific cluster. Experts named the topics and document clusters based on various outputs from these semi-automatic methods. We identified and labelled 175 cardiovascular topics and 20 large document clusters, with concordance between the approaches. Overarching, strongly growing topics in clinical and population sciences are evidence-based guidance for treatment, research on outcomes, prognosis, and risk factors. 'Hot' topics include novel treatments in valve disease and in coronary artery disease, and imaging. Basic research decreases its share over time but sees substantial growth of research on stem cells and tissue engineering, as well as in translational research. Inflammation, biomarkers, metabolic syndrome, obesity, and lipids are hot topics across population, clinical and basic research, supporting integration across the cardiovascular field. CONCLUSION: Growth in clinical and population research emphasizes improving patient outcomes through novel treatments, risk stratification, and prevention. Translation and innovation redefine basic research in cardiovascular disease. Medical need, funding and publishing policies, and scientific opportunities are potential drivers for these evolutions.

Original languageEnglish
Pages (from-to)2363-2374
Number of pages12
JournalEuropean heart journal
Volume40
Issue number28
DOIs
Publication statusPublished - Jul 21 2019

Fingerprint

Publications
Research
Cardiovascular Diseases
Natural Language Processing
Population
Cell Engineering
Translational Medical Research
Tissue Engineering
Growth
Coronary Artery Disease
Therapeutics
Obesity
Biomarkers
Medicine
Outcome Assessment (Health Care)
Inflammation
Lipids

Keywords

  • Cardiovascular research
  • Clinical care
  • Innovation
  • Outcomes
  • Prevention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Hot topics and trends in cardiovascular research. / Gal, Diane; Thijs, Bart; Glänzel, W.; Sipido, Karin R.

In: European heart journal, Vol. 40, No. 28, 21.07.2019, p. 2363-2374.

Research output: Contribution to journalArticle

Gal, Diane ; Thijs, Bart ; Glänzel, W. ; Sipido, Karin R. / Hot topics and trends in cardiovascular research. In: European heart journal. 2019 ; Vol. 40, No. 28. pp. 2363-2374.
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