Host-guest interactions in poly(N-isopropylacrylamide) gel: A thermoanalytical approach

Eniko Manek, Attila Domján, Alfréd Menyhárd, K. László

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Abstract Responsive hydrogels are one of the most frequently proposed vehicles for targeted and controlled drug delivery. Interaction between the transported drug and the three-dimensional polymer network could compromise the kinetics and the efficiency of delivery in thermoresponsive polymers. Poly(N-isopropylacrylamide) (PNIPA) gel was equilibrated with excess 500 mM aqueous solutions of three model drug molecules, phenol, ibuprofen and dopamine. These molecules affect the swelling properties of PNIPA in different ways. After determining the drug uptake and drying to constant mass, the loaded samples were studied with simultaneous thermal analysis. The difference in thermal response is interpreted in terms of the different typical molecular interactions in these systems under confined conditions. For phenol and dopamine, the water-phenol and dopamine-dopamine interactions, respectively, are stronger than that between the guest and polymer. For ibuprofen-PNIPA, the synergy in the thermal decomposition may stem from a strong polymer-ibuprofen relation.

Original languageEnglish
Article number4388
Pages (from-to)1273-1281
Number of pages9
JournalJournal of Thermal Analysis and Calorimetry
Volume120
Issue number2
DOIs
Publication statusPublished - May 1 2015

Fingerprint

dopamine
Ibuprofen
Dopamine
Polymers
drugs
Phenol
Gels
gels
phenols
polymers
delivery
interactions
Pharmaceutical Preparations
Controlled drug delivery
Molecules
Hydrogels
Molecular interactions
molecular interactions
stems
swelling

Keywords

  • Dopamine
  • Host-guest interactions
  • Ibuprofen
  • Phenol
  • Poly(N-isopropylacrylamide) gel
  • Temperature-sensitive polymers

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Condensed Matter Physics

Cite this

Host-guest interactions in poly(N-isopropylacrylamide) gel : A thermoanalytical approach. / Manek, Eniko; Domján, Attila; Menyhárd, Alfréd; László, K.

In: Journal of Thermal Analysis and Calorimetry, Vol. 120, No. 2, 4388, 01.05.2015, p. 1273-1281.

Research output: Contribution to journalArticle

Manek, Eniko ; Domján, Attila ; Menyhárd, Alfréd ; László, K. / Host-guest interactions in poly(N-isopropylacrylamide) gel : A thermoanalytical approach. In: Journal of Thermal Analysis and Calorimetry. 2015 ; Vol. 120, No. 2. pp. 1273-1281.
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